One way to play Uno: Show Em No Mercy with a standard deck of cards. Based on Discord's Blazing 8's. I thought this mapping would be the most intuitive, with most of the actions being tied to high cards.
A quick view reference for the Ducky One 3 model keyboard confinguration keybinds. This reference is taken from the user manual for the fullsize RGB keyboard and verified for accuracy. It may differ in parts to the smaller non-full size keyboards.