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Heparin Drug Info (exam 3)
Action
Blocks Prothrombin to Thrombin |
Indications
Prevents formation of clots |
Pulmonary embolism & thrombus |
Drug of Choice For: |
DIC |
Contraindications
Beef/Pork allergies or cultural/religious objections |
Thrombocytopenia |
Bleeding disorder |
Cautions
Uncontrolled HTN: Heparin makes vessels more friable which could result in a fatal bleed |
Recent surgery |
GI ulcers |
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Adverse Effects
Heparin induced thrombocytopenia with thrombosis (HITT) |
Thrombocytopenia |
Drug Interactions
Anticoagulants |
Penicillin |
Antihistamines |
Digoxin |
Nitroglycerin |
Nicotine |
All of these drugs will exacerbate the effects of Heparin
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Nursing Interventions
Monitor Labs: CBC & PTT |
Assess for therapeutic drug effect & development of AE |
Antidote: Protamine Sulfate |
Administer in the event of Heparin overdose |
Administration Route: |
SubQ or IV |
Half-life |
90 min. |
Injection site may form Hematoma |
IV site will ooze and have more evident bruising |
Drug of Choice for Bridge to other anticoagulants such as Warfarin
Labs
PTT |
Therapeutic range = 45-70 sec. |
CBC |
Monitor for thrombocytopenia (<150) |
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