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Drug info for pioglitazone
Prototype
Pioglitazone |
Rosiglitazone |
Action
Decrease insulin resistance |
Indication
Used to treat Type 2 Diabetes |
Contraindications
Active liver disease |
History of bladder cancer |
Severe heart failure |
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|
BLACK BOX WARNING
Congestive Heart Failure |
Shortness of breath, Edema, Crackles/Rales |
Adverse Effects
Hepatotoxicity |
Cognitive Heart Failure |
Weight Gain |
Fluid Retention |
Drug Interactions
Will increase blood glucose levels |
Statins |
Will increase/decrease blood glucose levels |
Zoles, Rifampin, Cimetidine |
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|
Nursing Interventions
Monitor A1C and LFTs |
Monitor for signs & symptoms of CHF |
May take up to 12 weeks for max effects |
Normal Range for Lab Values
AST |
10-40 |
ALT |
7-56 |
A1C |
Goal: <6.5 |
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