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Thiazolidinediones Cheat Sheet by

Drug info for pioglitazone

Prototype

Piogli­tazone
Rosigl­itazone

Action

Decrease insulin resistance

Indication

Used to treat Type 2 Diabetes

Contra­ind­ica­tions

Active liver disease
History of bladder cancer
Severe heart failure
 

BLACK BOX WARNING

Congestive Heart Failure
Shortness of breath, Edema, Crackl­es/­Rales

Adverse Effects

Hepato­tox­icity
Cognitive Heart Failure
Weight Gain
Fluid Retention

Drug Intera­ctions

Will increase blood glucose levels
Statins
Will increa­se/­dec­rease blood glucose levels
Zoles, Rifampin, Cimetidine
 

Nursing Interv­entions

Monitor A1C and LFTs
Monitor for signs & symptoms of CHF
May take up to 12 weeks for max effects

Normal Range for Lab Values

AST
10-40
ALT
7-56
A1C
Goal: <6.5
 

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