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Low Molecular Weight Heparin Cheat Sheet by

Drug info for Enoxaparin

Prototype

Enoxaparin

Action

Blocks factors XA and IIA in clotting cascade

Indica­tions

DOC in hospit­alized patients because it doesn't have massive systemic effects

BLACK BOX WARNING

Spinal block/­epi­dural: hematoma or bleeding may occur causing permanent neurol­ogical damage
 

Drug Intera­ctions

Anti-p­latelet drugs increase risk of thromb­ocy­topenia

Adverse Effects

Thromb­ocy­topenia
Toxicity (only if wrong dose is given)
Neurol­ogical damage (r/t BBW)

Admini­str­ation

Route: SubQ
Onset: 3-5 hours
Half-life: 2-4 times longer than heparin
Dosing: weight based --> predic­table dose response
 

Nursing Implic­ations

No required lab monitoring d/t predic­table dose response
Instruct patient on self-a­dmi­nis­tration
Monitor for bleeding
 

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