Local anaesthetic agents provide complete loss of sensory modalities.
Henderson- Hasselbach Equation:
Pharmacokinetics of Local Agents:
Mechanism of Action:
Path to receptor site:
Interaction with Sodium Channels:
> Pre-medication with Benzodiazepines can prevent CNS side effects
Local anesthetic agents used with a vasoconstrictor:
> localised neuronal uptake
> adrenaline can potentiate neurotoxicity of LA
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