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% Document Info
\author{Carm (Carmilaa)}
\pdfinfo{
  /Title (local-anesthetic-agents.pdf)
  /Creator (Cheatography)
  /Author (Carm (Carmilaa))
  /Subject (Local Anesthetic Agents Cheat Sheet)
}

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% Header and Footer
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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Local Anesthetic Agents Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Carm (Carmilaa)} via \textcolor{DarkBackground}{\uline{cheatography.com/49544/cs/16833/}}}
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\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Carm (Carmilaa) \\
  \uline{cheatography.com/carmilaa} \\
  \end{tabulary}
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\columnbreak
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 28th August, 2018.\\
   Updated 28th August, 2018.\\
   Page {\thepage} of \pageref{LastPage}.
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
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% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Local Anaesthesia:}}}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{- Loss of sensation in a limited region of the body} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{- Localized analgesia} \tn 
% Row Count 3 (+ 1)
% Row 2
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\mymulticolumn{1}{x{5.377cm}}{- Drug delivered to target} \tn 
% Row Count 4 (+ 1)
% Row 3
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\mymulticolumn{1}{x{5.377cm}}{- aka "regional anesthesia"} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\mymulticolumn{1}{x{5.377cm}}{Local anaesthetic agents {\bf{provide complete loss of sensory modalities}}.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Classification:}}}}  \tn
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Henderson- Hasselbach Equation:}}}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{\textgreater{} Uncharged form is more lipid soluble} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{\textgreater{} Lower the pKa, the greater the percentage of unchanged weak base at a given pH} \tn 
% Row Count 3 (+ 2)
% Row 2
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\mymulticolumn{1}{x{5.377cm}}{\textgreater{} {\bf{Basic drugs: more will be lipid soluble form at alkaline pH}}} \tn 
% Row Count 5 (+ 2)
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\par\addvspace{1.3em}

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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Pharmacokinetics of Local Agents:}}}}  \tn
% Row 0
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\mymulticolumn{2}{x{5.377cm}}{\textgreater{} Exists as weak bases} \tn 
% Row Count 1 (+ 1)
% Row 1
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\textgreater{} pKa of most LA agents ranges 7.5 to 9.0 & mainly exist in cationic form at physiologic pH \tn 
% Row Count 4 (+ 3)
% Row 2
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\textgreater{} Benzocaine (pKa 3.5) & exists mainly in non-ionized form at physiological pH \tn 
% Row Count 7 (+ 3)
% Row 3
\SetRowColor{white}
\textgreater{} Cationic form is most active at receptor site & receptor site at the inner vestibule of the sodium channel \tn 
% Row Count 10 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Mechanism of Action:}}}}  \tn
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\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{\textgreater{} Block voltage-gated sodium channels \newline \textgreater{} During excitation, sodium channels are opened= \newline                               - Sodium influx \newline                               - Opening of sodium channels result in depolarization}  \tn 
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Interaction with Sodium Channels:}}}}  \tn
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Adverse Effects:}}}}  \tn
% Row 0
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{\bf{CNS}} & sedation, light headedness, visual and auditory disturbances \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & tongue numbness and metallic taste \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & tonic-clonic convulsions (at higher dose) \tn 
% Row Count 7 (+ 2)
% Row 3
\SetRowColor{white}
{\bf{Cardiotoxicity:}} & Profound effects on conduction and function \tn 
% Row Count 9 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Heart Block \tn 
% Row Count 10 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{\textgreater{} Pre-medication with {\bf{Benzodiazepines}} can prevent CNS side effects}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.04057 cm} x{2.93643 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{{\bf{Clinical Uses:}}}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Surface anesthesia:}} & lidocaine, benzocaine, tetracaine \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Infiltration anesthesia:}} & most agents, minor surgeries \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
{\bf{Nerve block:}} & most agents, for surgery, dentistry and analgesia. \tn 
% Row Count 7 (+ 3)
% Row 3
\SetRowColor{white}
{\bf{Spinal anesthesia:}} & mainly lidocaine \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Local anesthetic agents used with a {\bf{vasoconstrictor}}: \newline                          \textgreater{} localised neuronal uptake \newline                          \textgreater{} adrenaline can potentiate neurotoxicity of LA}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}