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Each tca cycle produces:
Two molecules of carbon dioxide. |
Three molecules of NADH. |
Three hydrogen ions. |
One molecule of FADHâ‚‚ |
One molecule of GTP. |
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Outline
The two carbon atoms that enter the cycle as the acetyl group. |
the enzymes of the citric acid cycle are physically associated with one another. |
Substrate channeling; Metabolon |
The cycle operates only under aerobic conditions, although oxygen does not participate directly in the cycle. |
The pyruvate dehydrogenase complex is regulated allosterically and by reversible phosphorylation |
ATP->ADP, H2O->Pi |
TCA cycle is controlled at several points
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TCA cycle-Source of Biosynthetic Precursors
Outline
The citric acid cycle must be capable of being rapidly replenished if any are drawn off for biosynthesis, to allow the cycle to function |
acetyl CoA can not convert into oxaloacetate or any other citric acid cycle intermediate |
oxaloacetate can be formed by the carboxylation of pyruvate, a crucial role in gluconeogenesis, which is active only in the presence of acetyl CoA |
Pyruvate to Oxaloacetate
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