Types of Wound HealingPrimary Intention Healing | Healing by a non-infected and uninterrupted surgical incision | | Typically held by sutures or other physical support | | Not as much cell death or tissue loss, very predictable healing | Second Intention Healing | Requires removal of necrotic tissue due to increased cell death | | Much slower healing process, leads to scar tissue |
Wound Healing in shortVascular Response | hemostasis - Goal is to control bleeding | Inflammatory Response | Inflammation- Goal is to clean debris/bacteria and prevent infection | Proliferative Phase | granulation, epithelialization (the active growth phase). Goal is reconstruction/scar tissue formation | Maturation Phase | reconstructive phase- goal is to remodel |
| | Factors Influencing Wound HealingDiabetes | Poor circulation which slows down the blood which makes it harder to deliver nutrients to wound. | | Decreased production of new blood vessels growth and healing hormones | | Glucose in blood and urine is energy source for bacteria (leads to infections) | | Depression of the antioxidant system and humoral immunity (leads to infections) | | Neuropathy. They cannot feel pain so they won't know if a wound is getting worse/infected. | | Elevated glucose levels decrease the functioning of red blood cells carrying nutrients to the injured area and limit the effectiveness of white blood cells fighting infections. | | The inflammation stage frequently lasts too long and the wound can become chronic. In chronic wounds, the balance between producing and degrading collagen is lost and the wounds don't heal. | Nutrition, perfusion, immune status, infection, age | Wound Environment | wound type, size, location, type, depth |
| | WoundsDefinition | A wound is a break in the continuity of soft tissues | | Caused by a chemical, physical or biological insult | Types of Wounds | Incised, lacerated, penetrated, perforating, punctured, gunshot, abrasion, avulsion, bite, ulcerating, granulating, septic/aseptic, closed |
Aseptic = clean wound
septic = infected wound
Macrophages-Critical cells because they secrete AGF | -Produce a host of cytokines and growth factors and act as chemoattractants to the other cells needed for tissue repair | -Convert macromolecules to amino acid and sugars necessary for wound healing | -Bring in contractual cells to encourage wound contraction |
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