Types of Wound Healing
Primary Intention Healing
Healing by a non-infected and uninterrupted surgical incision
Typically held by sutures or other physical support
Not as much cell death or tissue loss, very predictable healing
Second Intention Healing
Requires removal of necrotic tissue due to increased cell death
Much slower healing process, leads to scar tissue
Wound Healing in short
hemostasis - Goal is to control bleeding
Inflammation- Goal is to clean debris/bacteria and prevent infection
granulation, epithelialization (the active growth phase). Goal is reconstruction/scar tissue formation
reconstructive phase- goal is to remodel
Factors Influencing Wound Healing
Poor circulation which slows down the blood which makes it harder to deliver nutrients to wound.
Decreased production of new blood vessels growth and healing hormones
Glucose in blood and urine is energy source for bacteria (leads to infections)
Depression of the antioxidant system and humoral immunity (leads to infections)
Neuropathy. They cannot feel pain so they won't know if a wound is getting worse/infected.
Elevated glucose levels decrease the functioning of red blood cells carrying nutrients to the injured area and limit the effectiveness of white blood cells fighting infections.
The inflammation stage frequently lasts too long and the wound can become chronic. In chronic wounds, the balance between producing and degrading collagen is lost and the wounds don't heal.
Nutrition, perfusion, immune status, infection, age
wound type, size, location, type, depth
A wound is a break in the continuity of soft tissues
Caused by a chemical, physical or biological insult
Types of Wounds
Incised, lacerated, penetrated, perforating, punctured, gunshot, abrasion, avulsion, bite, ulcerating, granulating, septic/aseptic, closed
Aseptic = clean wound
septic = infected wound
-Critical cells because they secrete AGF
-Produce a host of cytokines and growth factors and act as chemoattractants to the other cells needed for tissue repair
-Convert macromolecules to amino acid and sugars necessary for wound healing
-Bring in contractual cells to encourage wound contraction