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% of cheat sheets but are needed for some symbol support.
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% Document Info
\author{happyfeet2020}
\pdfinfo{
  /Title (tissue-repair-and-wound-healing.pdf)
  /Creator (Cheatography)
  /Author (happyfeet2020)
  /Subject (Tissue Repair and Wound Healing Cheat Sheet)
}

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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Tissue Repair and Wound Healing Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{happyfeet2020} via \textcolor{DarkBackground}{\uline{cheatography.com/144934/cs/31292/}}}
\end{tabulary}
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}happyfeet2020 \\
  \uline{cheatography.com/happyfeet2020} \\
  \end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 11th April, 2022.\\
   Updated 13th April, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
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% Set font size to small. Switch to any value
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% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{x{2.09034 cm} x{2.88666 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Types of Wound Healing}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Primary Intention Healing}} & Healing by a non-infected and uninterrupted surgical incision \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & Typically held by sutures or other physical support \tn 
% Row Count 6 (+ 3)
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\SetRowColor{LightBackground}
 & Not as much cell death or tissue loss, very predictable healing \tn 
% Row Count 9 (+ 3)
% Row 3
\SetRowColor{white}
{\bf{Second Intention Healing}} & Requires removal of necrotic tissue due to increased cell death \tn 
% Row Count 12 (+ 3)
% Row 4
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 & Much slower healing process, leads to scar tissue \tn 
% Row Count 15 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Three Phases of Wound Healing}}  \tn
% Row 0
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{\bf{1) Inflammatory Phase}} & Immediate to 2-5 days; hemostasis and inflammation \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & Starts with clot formation and the migration of phagocytic wbc in the wound site. First cells to arrive are neutrophils which ingest and remove bacteria and cellular debris. After 24 hours, macrophages come and ingest cellular debris and play a role in production of growth factors for proliferative phase \tn 
% Row Count 16 (+ 13)
% Row 2
\SetRowColor{LightBackground}
 & Granulation tissue fills any void. Collagen present but oriented vertically. Proliferation of epithelial cells continue leading to thicker epithelial layer \tn 
% Row Count 23 (+ 7)
% Row 3
\SetRowColor{white}
{\bf{2) Proliferative Phase}} & 2 days to 3 weeks; granulation, contraction, epithelialization \tn 
% Row Count 26 (+ 3)
% Row 4
\SetRowColor{LightBackground}
 & Focus is to build new tissue to fill the wound space.Proliferation of fibroblasts and vascular endothelial cells to form granulation tissue which fills the wound space. \tn 
% Row Count 33 (+ 7)
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Three Phases of Wound Healing (cont)}}  \tn
% Row 5
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 & Fibroblasts synthesizes and secretes the collage, proteoglycans, and glycoproteins needed for wound healing. They also produce growth factors that induce angiogenesis and endothelial cell proliferation and migration. \tn 
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% Row 6
\SetRowColor{white}
 & Epithelialization is the final component where epithelial cells at the wound edges proliferate to form a new surface layer. Requires a moist vascular wound. \tn 
% Row Count 16 (+ 7)
% Row 7
\SetRowColor{LightBackground}
{\bf{3) Remodelling Phase}} & 3 weeks to 1 year; collagen formation, increase in tensile strength \tn 
% Row Count 19 (+ 3)
% Row 8
\SetRowColor{white}
 & Development of the fibrous scar. There is a decrease in vascularity and continued remodelling of scar tissue by simultaneous synthesis of collagen by fibroblasts and lysis by collagenase enzymes. These two processes lead to the scar becoming reoriented to increase its tensile strength. \tn 
% Row Count 31 (+ 12)
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\mymulticolumn{2}{x{5.377cm}}{{\emph{Granulation tissue is formed from the proliferation of fibroblasts and vascular endothelial cells. It contains capillaries, fibroblasts and residual inflammatory cells.  \newline }}At Day 4-5 of wound healing, the epidermis resumes normal thickness and begins keratinization process. \newline *Excessive granulation tissue- when it continues to reproduce itself and forms and extends above the border and prevent proper epithelialization. Therefore, the wound cannot heal.}  \tn 
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Wound Healing in short}}  \tn
% Row 0
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Vascular Response & hemostasis - Goal is to control bleeding \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Inflammatory Response & Inflammation- Goal is to clean debris/bacteria and prevent infection \tn 
% Row Count 5 (+ 3)
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\seqsplit{Proliferative} Phase & granulation, epithelialization (the active growth phase). Goal is reconstruction/scar tissue formation \tn 
% Row Count 9 (+ 4)
% Row 3
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Maturation Phase & reconstructive phase- goal is to remodel \tn 
% Row Count 11 (+ 2)
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Factors Influencing Wound Healing}}  \tn
% Row 0
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Diabetes & Poor circulation which slows down the blood which makes it harder to deliver nutrients to wound. \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
 & Decreased production of new blood vessels growth and healing hormones \tn 
% Row Count 7 (+ 3)
% Row 2
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 & Glucose in blood and urine is energy source for bacteria (leads to infections) \tn 
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\SetRowColor{white}
 & Depression of the antioxidant system and humoral immunity (leads to infections) \tn 
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% Row 4
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 & Neuropathy. They cannot feel pain so they won't know if a wound is getting worse/infected. \tn 
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 & Elevated glucose levels decrease the functioning of red blood cells carrying nutrients to the injured area and limit the effectiveness of white blood cells fighting infections. \tn 
% Row Count 24 (+ 7)
% Row 6
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 & The inflammation stage frequently lasts too long and the wound can become chronic. In chronic wounds, the balance between producing and degrading collagen is lost and the wounds don't heal. \tn 
% Row Count 31 (+ 7)
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\begin{tabularx}{5.377cm}{x{1.4931 cm} x{3.4839 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Factors Influencing Wound Healing (cont)}}  \tn
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\mymulticolumn{2}{x{5.377cm}}{Nutrition, perfusion, immune status, infection, age} \tn 
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% Row 8
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Wound Environment & wound type, size, location, type, depth \tn 
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Wounds}}  \tn
% Row 0
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{\bf{Definition}} & A wound is a break in the continuity of soft tissues \tn 
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% Row 1
\SetRowColor{white}
 & Caused by a chemical, physical or biological insult \tn 
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% Row 2
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{\bf{Types of Wounds}} & Incised, lacerated, penetrated, perforating, punctured, gunshot, abrasion, avulsion, bite, ulcerating, granulating, septic/aseptic, closed \tn 
% Row Count 10 (+ 6)
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\mymulticolumn{2}{x{5.377cm}}{Aseptic = clean wound \newline septic = infected wound}  \tn 
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Macrophages}}  \tn
% Row 0
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-Critical cells because they secrete AGF & -Produce a host of cytokines and growth factors and act as chemoattractants to the other cells needed for tissue repair \tn 
% Row Count 6 (+ 6)
% Row 1
\SetRowColor{white}
-Convert macromolecules to amino acid and sugars necessary for wound healing & -Bring in contractual cells to encourage wound contraction \tn 
% Row Count 10 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}