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Drug Classes & Actions : NSAIDs Cheat Sheet by

NSAIDs: Generic & Trade Names, MOA, Indications, Side Effects, Monitoring Parameters, Notes

Commonly Prescribed For...

Arthritis
Post-O­per­ative Pain
Acute Gout
Inflam­matory Pain r/t Tissue Injury
Dysmen­orrhoea
Fever
Headache & Migraine
Lower Back Pain
Renal Colic
Macular Edema

Indica­tions

Antipy­retic
Fever Reduction
Analgesic
Pain Relief
Antith­rom­botic
Reduces Blood Clotting
Anti-I­nfl­amm­atory
Reduces Inflam­mation

Mechanism Of Action - Enzyme Inhibitor

Inhibits Cycloo­xyg­enase (COX): COX-1 and COX-2 helps in the production of prosta­gla­ndins, which are respon­sible for aiding the inflam­matory response by acting as a vasodi­lator and inhibiting the aggreg­ation of blood platelets.
Antipyretic Proper­ties: Can be used to treat fever. Works on the hypoth­alamus by inhibiting prosta­glandin E2 (PGE2) via COX, which raises the thermal set point.
COX-1 acts on the mucosa lining of the stomach to keep it from being eroded away by stomach acid.
COX-2 does not act on the lining of the stomach, so certain NSAIDs which work on COX-2 but not COX-1 are preferable to keep the function of the stomach intact and protected.

Generic & Trade Names

Gene­ric
Trade
Route
Diclofenac
Voltaren
Oral,
Ibuprofen
Advil, Motrin
Oral, Parenteral
Naproxen
Aleve
Oral
COX-2 Select­ive
Celecoxib
Celebrex
Mornif­lumate
Etoricoxib
Nimesulide
Parecoxcib
Talnif­lumate

Name Endings

-Coxib
COX-2 inhibitor
-Profen
Anti-i­nfl­amm­ato­ry/­Ana­lgesic
-Fenac
Anti-i­nfl­amm­atory Agent

Precau­tions

Not Recomm­ended For...
Pregnancy
Cardio­vas­cular Disease
Renal Disease
GI Bleeds (history of & currently)
Uncont­rolled Hypert­ension

Intera­ctions

Interactions
Increases
Decreases
Aspirin
GI Side Effects
Effect­iveness of NSAID
Diuretics
 
Effects of Diurectic
Antihy­per­tensive
 
Effects of Antihy­per­ten­sives
 

Side Effects

Gastro­int­estinal Ulcers & Bleeds
Dry Eyes
Myocardial Infarction
Dizziness
Nephro­pathy
Diarrhea
Raised Liver Enzymes
Nausea
Hypert­ension
Dyspepsia
Salt & Fluid Retention
Bronch­ospasms

Pharma­cod­yna­mic­s/K­inetics

 
Oral
Serum
Onset
30-60 Minutes
.
Peak
2-4 Hours
2-2.5 Hours
Duration
6-8 Hours
.
Absorption
Rapid
Readily

Nursing Diagnoses

Nursing Diagno­ses
Acute Pain
Indications
Risk for imbalanced body temper­ature
Indications
Deficient knowledge r/t 1. disease process or/and 2. medication regimen
Indicates Teaching

Assess­ments

Assessment
Foll­owing Administration
Pain
Limitation of movement, type, location, intensity
Fever
note associated signs (diaph­oresis, tachyc­ardia, malaise, chills)

Laboratory Test Consid­era­tions

What
Focus
CBC
GI Effects
Pain, Bleeding, Bruising, Dyspepsia
Renal Function
Urine Output, Serum BUN, Creatinine
Response
Pain, ROM, Grip Strength, Mobility, ADL Functions
Liver Functions

Patient Education

Take NSAIDs with meals or a glass of milk.
Remain upright for 15-30 minutes after taking NSAIDs.
Avoid use of alcohol to prevent GI ulceration & Bleeding
Do not take in combin­ation with other NSAIDs, acetam­ino­phen, and salicy­lates.
Avoid taking for long periods of time, advise COX-2 inhibitor NSAID use and stomach protectant (Ex. Pantop­ora­zole)
Avoid taking before surgery

ADDITIONAL NOTES

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References

                       

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Metadata

  • Languages:
  • Published: 25th October, 2018
  • Last Updated: 22nd December, 2018
  • Rated: 5 stars based on 2 ratings

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