DM 1: autoimmune response, kills Beta cells of pancreas; KETOacidosis results from beta-oxidation of lipids = decreased plasma pH; INTINSIVE monitoring with frequent dosing of insulin
DM 2: pancreas produces insulin, but target cells can't respond properly to the insulin signal
Common: hyperglycemia, hypoglycemia, neuropathy, damage to blood vessels - especially KIDNEYS, BRAIN, RETINA, and LOWER EXTREMETIES.
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