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Action, Indication, CI, C, AE, DI, & NI
Action
Blocks Vitamin K at sites of action |
Indications
-May be used with children
-Decrease dose with elderly patients
Contraindications
Blood disorders |
Hepatic Disease |
GI Ulceration |
All above diseases + warfarin can cause fatal bleeding
Pregnancy Category X
Fetal Warfarin Syndrome (FWS) |
Developmental delays |
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Low birth weight |
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Poor growth |
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Drug Interactions
Increase effects of warfarin: |
Decrease Warfarin Effects: |
-NSAIDS |
-Birth Control |
-Bactrim |
-Spironolactone |
-PPIs |
-Haldol |
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-H2 blockers |
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-Aprepitant |
Administration
Half-life = 24-72 hrs |
Remains in system 4-5 days |
PO at night at the same time |
*highly protein bound therefore absorption is heavily impacted by food and protein levels in body
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Nursing Interventions
Monitor Labs: CBC & PT/INR |
Administer antidote if OD occurs |
Vitamin K |
Educate pt. about diet |
Instruct patient to eat the same amount of foods containing vitamin K every week |
Emaciate Patients |
Not DOC because the decrease protein in blood increase risk of toxicity |
Expected Lab values
CBC |
no indication of thrombocytopenia |
PT |
18-30 seconds |
INR |
2-3 |
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