Anti-anginals and VD Cheat Sheet (DRAFT) by sam219

Nitroglycerin	Isosorbide dinitrate	Amyl nitrite (Isopentyl nitrite)
Sublingual in emerge­ncies with rapid action but very short half life.	Better oral bioava­ila­bility and longer half life (1hr)	Inhaled volatile liq.
Photos­ens­itive and tolerance is possiable		Not recomm­ended due to flushing.

Dihydr­opy­ridines	Aralkyl amine deri.	Benzot­hia­zepine
-Nifed­ipine-	-Verap­amil-	-Dilti­azem-
the prototype; potent VD	ttt of angina, arrythmia, HTN	Less potent for arrythmia
for HTN, angina.	chiral molecule with levoro­tatory as most potent form	for variant angina
NOT for arrythmia due to no or little effect on heart nodes.
NO2 (nitro gp) essential for activity.
Amlodipine
Longer t1/2 but lesser -ve inotropy due to more vascular select­ivity.
-Felod­ipine, Nicard­ipine-

Aspirin	Dipyri­damole	Thieno­pyr­idine deriv.
	Non-ni­trate	Purine­-re­ceptor blockers on platlets to stop aggreg­ation activation
	Potent­iates PGI2 (prost­acy­clin)	-Ticlo­pidine-
	Essent­ially, increases presence of the VD adenosine.	SE: neutro­penia
	prophy­laxis for chronic angina pectoris.	-Clopi­dogrel-
		reduced neutro­penia