Genetic and Evolution
Charles Darwin - Theory of evolution |
Natural Selection is a theory developed through his observations of the fitness of species characteristics to its environment |
Natural selection and fitness |
Animals that have certain traits that get an advantage |
Evolution is a slow process |
Fitness - organisms that are going to survive |
not good enough that you survive, must pass traits on |
Survival Adaptation
obtain food for yourself |
physical traits |
camo |
all these adaptation make your chance greater for survival |
Reproductive adaptation
passing on genes to the next generations |
some genes less useful, but are needed for reproduction |
make animals more desirable to the opposite sex |
example: abs, plumage of peacocks |
Intrasexual
are then passed on with greater frequency due to their association with greater mating sucess |
when males fight with other males to win over the female |
pressure on males to succeed |
not always a physical deal - example: Satin bird |
Intersexual Selection
in this process, if members of one sex are attracted to certain qualities in mates |
example: brilliant plumagem, signs of good health, or even intelligence |
female can select the winner |
which one has the best genes/traits |
Evolution of Modern Humans
first brain cell: 700 mya |
cell moving towards heat or light |
starts getting collection of brain cell to work together and produce basic brain function |
first brain cell: 250 mya |
first primate brain: 7 mya |
humans and chimpanzees share common ancestors about 7 million years ago |
modern humans are relatively recent in geological record |
substantial physiological and cognitive changes compared to earlier species |
Australopithecus: Our distant ancestor
irst primate to show distinctly human characteristics |
walk on two legs, chimpanzee walk on 2 but not very well |
spending a lot of time on the ground than in trees on 2 legs |
how smart, overall: as a modern chimpanzee |
judged by tool use and tool making |
chimpanzee can use tools but do not make them |
australopithecus, could also not make them, but could use them |
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Hominids: the earliest humans
homo habilis (handy human) manufacture simple stone tools |
homo erectus (upright human) around on earth longer than we have been around |
neanderthals - better stone tools and higher intelligence |
Evolution of Modern Humans
adaptations to a changing environment |
bipedalism |
change in diet -> smaller facial muscles and teeth |
not just focusing on meat but now fruit |
allows cooking to soften the meal, we don't have big teeth = everything gets smaller |
smaller facial muscles and teeth -> greater range of vocalization -> language |
small changes to mouth, more room for vocal track |
produce language |
cognitive ability |
better tool making ability |
social organization -> culture |
from early to modern humans, brain size and cognitive ability increases |
genetics
every cell in an organisms body contains the genetic blueprint for that organism |
human body -> cell -> chromosomes -> DNA -> Gene |
gene -> protein -> expression |
genotype - blueprint examples: blue eyes, plans is housed the gene themselves |
phenotype - the physical expressions of the genotype example: person has blue eyes |
complex things break down to simple ideas |
four basic bases, which are linked to each other |
adenine bonds with thymine |
cytosine bonds with quanine |
Gene to protein
the sequence of bases in gene determines which amino acids are used to build the specified protein |
sequences of bases code for specific amino acids |
bases -> amino acids -> proteins |
amino acids to protein
amino acids |
linked together by a peptide bond |
a polypeptide amino acids chain forms a protein |
proteins are required to maintain cell function |
proteins typically degrade within days |
DNA ->mRNA -> Amino acid chain |
transcription and traslation |
mRNA leaves nucleus and moves to endoplasmic reticulum |
translates into different amino acids that need to be built |
ribosomes move along translates the mRNA and codes for amino acids |
codon codes for a specific amino acid |
amino acids are chained together to make protein |
golgi body is packaged into vesicles and transported into different parts of the cell |
Genetic techniques
introduce or remove genes of an embryo |
knock in / knock out : Fur colour in mice, gene for genetic disorder, |
knock in : mouse that is supposed to have white fur, introduce genes for black fur |
knock out : turn off gene |
genetic disorder, develop treatment, common practice in neuroscience |
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Animals model for human disorders
the mammalian brain is structurally similar across species |
animals models used to mimic human diseases such as Alzheimer's and Parkinson's |
introduce a gene into a rat then you can test treatment and you are not dealing with human subjects |
Genetic techniques
"maze bright" and "maze dull rats" |
selective breeding |
maze bright = rats that picked up learning the maze well |
maze dull = rats that did not learn it well |
only breed maze bright |
generation later keep smart rat together and non-smart together |
The human genome project
completed in 2003 |
human genetic code contains less than 30,000 genes |
4 bases that make it all up |
to what degree are human abilites genetically determined vs. linked environement |
genetics vs. what are you doing |
Identical twins
studying genetic disorders in identical twins |
monozygotic |
share the same genetic code |
identical twins raised apart share many of the same physical and personality traits |
individuals experiences |
measures data of identical twins who were raised apart and live in different environment |
can it be explained by genes or environment |
you tend to see the same traits in this twin which is a strong genetic link |
behavioural genetics are used to study genetic influence on a host of different behaviours |
strong influence of genetics but does not answer the whole story: learning disabilites, mental disabilites |
Epigenetics
how a person experience can effect their gene |
genes can explain variation between certain traits behaviours but not all |
epigenetic drift - differences |
when you observe the twin boys at a genetic level they are almost identical as well |
older in lifem you start to see differences. similarity start to become epigenetic drift because the different experinces they are having in life |
Epigenetic mechanisms
having their effects in this process |
DNA transcription |
histone modification - DNA does not get transcribed like it should. results in the protein that was not intended |
DNA modification |
they all represent how the plan can be changed |
critical during development when genes have to turn on and off at a precise interval |
silent genes to let it develop into a mature gene |
Environmental effects on the genome
diseases linked to environmental exposure are difficult to track |
different people respond differently |
person may not have a genetically exposed to lung cancer but if they take up smoking |
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