Everything basic about cholinergic drugs
Cholnergic Drugs intro
at Cholinergic synapsis- that use Ach as neurotransmitter
Previous cheat sheet
Increase activity at ACh line synapses.
Direct acting Cholinergic Stimulants
Bind directly with the Cholinergic receptor
Indirect acting Cholinergic stimulants
increase synaptic activity by inhibiting the ACh linesterase enzyme located at Cholinergic synapse
Direct Acting Cholinergic Stimulants
Function: similar to Ach Molecule
Is DIRECT ACTING Cholinergic stimulant
Muscurininc Cholinegic Stimulants
More beneficial , primarily AFFECT the peripheral tissues while exerting a minimal effect on the cholinergic receptors located in the autonomic ganglia and the neuromuscular junction.
only few are useful
Follow The Table
Indirect-acting Cholinergic Stimulants
increase activity at cholinergic synapses by inhibiting the Achsterase enzyme that is responsible for destroying Ach after this neurotransmitter is released from the presynaptic terminal.So it allows more Ach to remain in the Synapse. FINALLY: It increases in cholinergic synaptic transmission.
Also known as
Cholinesterase inhibitors / antichlinesterase agents
What it does finally
Exert a stimulatory effect on the peripheral muscuranic cholinergic synapses and on the cholinergic synapses found at the autonomic ganglia, at the skeletal neuromuscular junction, and within certain aspects of the CNS.
Problems and adverse effects
decrease in smooth muscle tone tha toccur in GI trct and bladder following abdominal surgery or trauma.
glaucoma, myasthenia gravis, alzheimer disease and to reverse the effects from an overdose of other drugs such as neuromuscular blocking agents and anticholinestergics.
Reversal of Neuromuscular blockage
Reversal of Ach-Induced CNS toxicity
Competitive antagonists of the postsynaptic Cholinergic receptors: So they bind reversibly to the cholinergic receptor but do NOT activate it.
BLOCKS the receptor from teh efects of endogenously released Ach ---> diminishing the cellular response to Cholinergic stimulation.
USED for Extreme High BP and Hypertensive emergencies
To produce Surgery by blocking the Skeletal NMJ
Antimuscarinic AntiCholinergic Drugs
Extract of plants such as belladonna and jimsonweed
BLOCK Postsynaptic Cholinergic Muscarinic Receptor
Five subtypes M1-M5
Antagonize cholinergic receptors on number of tissues which leads to side effects (see above Cheat sheet)
GI, Parkinson, and treat clinical disorder (table 19-2, p. 295)
Deficiency of the dopamine in the basal ganglia. --> leads to overactivity of central cholinergic synapse
Atropine- primarirly use to block vagus nerve on myocardium. Slows heart rate, conduction of the cardiac action postential thorughout the myoardium.
antimuscarinics - Scopolamine