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Progesterone Cheat Sheet by

Progesterone is used as a contraceptive, protection for clients on HRT, endometriosis, Dysfunctional uterine bleeding, and palliative treatment for advanced uterine cancer.

Drug Class: Proges­ter­one

Prototype Med
Medrox­ypr­oge­sterone Acetate
Other Meds
noreth­indrone (Micronor)
Megestrol acetate (Megace)
Action: Antagonize estrogen influenced tissue growth in the uterine endome­trium, thus prevent hyperp­lasia or an overgrowth of the lining of the uterus

Ther­apeutic Use

Treatment of endome­triosis
Treatment of dysfun­ctional uterine bleeding
Treatment of endome­trial carcinoma

Adverse Drug Reacti­ons

Thromb­oem­bol­ism­/Breast cancer
Breakt­hrough bleeding and other menstrual irregu­lar­ities

Nursing Interv­ent­ions

Monitor for and report any indica­tions of deep vein thromb­osis, pulmonary embolism, myocardial infarc­tion, and cerebr­ova­scular accident.
Encourage clients who smoke to quit.
Recommend mammograms and breast examin­ations at approp­riate intervals.
Discon­tinue the drug for any indica­tions of breast cancer.
Monitor the pattern and amount of any reported bleeding.
Inform clients that this effect diminishes with time.
Monitor weight.


Give orally daily or cyclically or via IM injection.
Expect amenorrhea and other menstrual irregu­lar­ities.

Patient Educat­ion

Report leg or chest pain, leg edema, sudden change in vision, severe head- ache, or shortness of breath.
Do not smoke.
Stop taking at least 4 weeks before any surgery that increases the risk of thromb­oem­bolic events.
Perform breast self-e­xam­ination every month.
Obtain a mammogram and breast examin­ation at the recomm­ended intervals.
Report any unusual breakt­hrough bleeding or spotting or changes in menstru- al patterns.
Take oral forms with food. Take at bedtime.


Pregnancy - terato­genic effects
History of or high risk for thromb­oem­bolic events
Undiag­nosed vaginal bleeding
Liver disease
Cervical, uterine, vaginal, or breast cancer


Cerebr­ova­scular accident
Cardiac or kidney dysfun­ction


Rifampin (Rifadin), ritonavir (Norvir), phenob­arbital (Luminal), carbam­azepine (Tegre­tol), primidone (Mysol­ine), phenytoin (Dilan­tin), and St. John’s wort can reduce the effect­iveness of proges­ter­ones.
Proges­terones may require adjust­ments in the dosage of hypogl­ycemic drugs.


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