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Progesterone is used as a contraceptive, protection for clients on HRT, endometriosis, Dysfunctional uterine bleeding, and palliative treatment for advanced uterine cancer.
Drug Class: ProgesteronePrototype Med | Medroxyprogesterone Acetate | | | Provera | Other Meds | norethindrone (Micronor) | | | Megestrol acetate (Megace) |
Action: Antagonize estrogen influenced tissue growth in the uterine endometrium, thus prevent hyperplasia or an overgrowth of the lining of the uterus Therapeutic UseTreatment of endometriosis | Treatment of dysfunctional uterine bleeding | Treatment of endometrial carcinoma |
Adverse Drug ReactionsThromboembolism/Breast cancer | Breakthrough bleeding and other menstrual irregularities | Nausea/Edema |
Nursing InterventionsMonitor for and report any indications of deep vein thrombosis, pulmonary embolism, myocardial infarction, and cerebrovascular accident. | Encourage clients who smoke to quit. | Recommend mammograms and breast examinations at appropriate intervals. | Discontinue the drug for any indications of breast cancer. | Monitor the pattern and amount of any reported bleeding. | Inform clients that this effect diminishes with time. | Monitor weight. |
AdministrationGive orally daily or cyclically or via IM injection. | Expect amenorrhea and other menstrual irregularities. |
| | Patient EducationReport leg or chest pain, leg edema, sudden change in vision, severe head- ache, or shortness of breath. | Do not smoke. | Stop taking at least 4 weeks before any surgery that increases the risk of thromboembolic events. | Perform breast self-examination every month. | Obtain a mammogram and breast examination at the recommended intervals. | Report any unusual breakthrough bleeding or spotting or changes in menstru- al patterns. | Take oral forms with food. Take at bedtime. |
ContrindicationsPregnancy - teratogenic effects | History of or high risk for thromboembolic events | Undiagnosed vaginal bleeding | Liver disease | Cervical, uterine, vaginal, or breast cancer |
PrecautionsAsthma/Siezures/Migraines | Cerebrovascular accident | Cardiac or kidney dysfunction |
InteractionsRifampin (Rifadin), ritonavir (Norvir), phenobarbital (Luminal), carbamazepine (Tegretol), primidone (Mysoline), phenytoin (Dilantin), and St. John’s wort can reduce the effectiveness of progesterones. | Progesterones may require adjustments in the dosage of hypoglycemic drugs. |
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