Progesterone is used as a contraceptive, protection for clients on HRT, endometriosis, Dysfunctional uterine bleeding, and palliative treatment for advanced uterine cancer.
Drug Class: Progesterone
Megestrol acetate (Megace)
Action: Antagonize estrogen influenced tissue growth in the uterine endometrium, thus prevent hyperplasia or an overgrowth of the lining of the uterus
Treatment of endometriosis
Treatment of dysfunctional uterine bleeding
Treatment of endometrial carcinoma
Adverse Drug Reactions
Breakthrough bleeding and other menstrual irregularities
Monitor for and report any indications of deep vein thrombosis, pulmonary embolism, myocardial infarction, and cerebrovascular accident.
Encourage clients who smoke to quit.
Recommend mammograms and breast examinations at appropriate intervals.
Discontinue the drug for any indications of breast cancer.
Monitor the pattern and amount of any reported bleeding.
Inform clients that this effect diminishes with time.
Give orally daily or cyclically or via IM injection.
Expect amenorrhea and other menstrual irregularities.
Report leg or chest pain, leg edema, sudden change in vision, severe head- ache, or shortness of breath.
Do not smoke.
Stop taking at least 4 weeks before any surgery that increases the risk of thromboembolic events.
Perform breast self-examination every month.
Obtain a mammogram and breast examination at the recommended intervals.
Report any unusual breakthrough bleeding or spotting or changes in menstru- al patterns.
Take oral forms with food. Take at bedtime.
Pregnancy - teratogenic effects
History of or high risk for thromboembolic events
Undiagnosed vaginal bleeding
Cervical, uterine, vaginal, or breast cancer
Cardiac or kidney dysfunction
Rifampin (Rifadin), ritonavir (Norvir), phenobarbital (Luminal), carbamazepine (Tegretol), primidone (Mysoline), phenytoin (Dilantin), and St. John’s wort can reduce the effectiveness of progesterones.
Progesterones may require adjustments in the dosage of hypoglycemic drugs.