Treatment of urinary urge incontinence caused by overactive bladder
Treatment of neurogenic bladder
Adverse Drug Reactions
Mydriasis (pupil dilation), dry eyes, blurred vision
Fever, heat exhaustion
Monitor for anticholinergic effects.
Monitor bowel elimination patterns.
Monitor urinary elimination patterns, especially in older adults.
Recommend periodic eye examinations
Monitor for headache
Monitor for dizziness and somnolence.
Advise clients to use caution in hot weather, as the drug suppresses sweating.
Take orally (either short-acting syrup or tablets) two to four times a day.
Take the extended-release (ER) tablets once a day.
Swallow ER tablets whole; do not crush or chew them.
Expect excretion of the insoluble shell of the ER tablets in stool.
Apply the transdermal patch twice a week to dry and intact skin on the abdomen, hip, or buttocks.
Rotate patch adhesion sites.
Gastrointestinal obstruction/Genitourinary obstruction
Active cardiac dysfunction
Urinary tract infection/Liver or renal disease
Hiatal hernia with reflux
Benign prostatic hypertrophy
Suck on hard candy/Sip water
Increase fluid and fiber intake and activity levels
Report any undesirable changes in urinary elimination (retention, infec- tion).
Use over-the-counter lubricating eye drops.
Obtain regular eye examinations (potential for glaucoma).
Report headache not relieved by over-the-counter analgesics.
Report dizziness or fainting.
Do not engage in dangerous activities if dizziness occurs or tends to recur.
Avoid becoming overheated.
Seek medical attention for fever and signs of heat exhaustion (muscle cramps, dizziness, nausea, vomiting).
CYP3A4 inhibitors (grapefruit juice, ketoconazole, erythromycin, itracon- azole [Sporanox], plus others) may increase toxicity.
CYP3A4 inducers (phenytoin [Dilantin], rifampin [Rifadin], carbamaze- pine [Tegretol], plus others) decrease effectiveness.