Class: Hormone Replacement Therapy
Conjugated Equine Estrogen
Transdermal Estradiol (Estraderm)
Estradiol Intravaginal Tablets (Vagirem)
Estradiol Cream (Estrace Vag. Cream)
Action:Estrogen works by binding to estrogen receptors in target tissues such as the genital organs, breasts, hypothalamus, and pituitary gland to maintain the functions of reproduction and feminization.
Relief of severe menopausal symptoms (vasomotor) and vulvar and vaginal atrophy
Prevention of postmenopausal osteoporosis
Adverse Drug Reactions
Thromboembolism: thrombophlebitis, pulmonary embolism, stroke, myocardial infarction
Endometrial hyperplasia, endometrial and ovarian cancer
Inform clients that this effect diminishes with time.
Monitor for and report any indications of deep vein thrombosis, pulmo- nary embolism, myocardial infarction, and cerebrovascular accident.
Encourage clients who smoke to quit smoking.
Use HRT for no more than 3 to 4 years to treat vasomotor or genital symptoms of menopause.
Monitor blood pressure.
Monitor for vaginal bleeding.
Advise a yearly pelvic examination
Check that clients who have an intact uterus are prescribed progester- one with their estrogen.
Take oral forms with food.
Report leg or chest pain, leg edema, sudden change in vision, severe headache, or shortness of breath.
Do not smoke.
Stop taking at least 4 weeks before any surgery that increases the risk of thromboembolic events.
Exercise regularly and follow a healthy, low-fat diet.
Take, apply, or instill at bedtime.
Obtain regular blood pressure checks.
Report persistent or recurrent vaginal bleeding.
Take according to the precise dosing schedule, typically continuously to avoid monthly bleeding. Take pills at the same time each day.
Transdermal estradiol patche
Apply patches at the recommended interval, typically once or twice per week.
Apply to clean, dry, intact skin on the abdomen or trunk (not breasts or waistline) and press firmly for 10 seconds. Do not use the same site more than once per week.
Intravaginal estradiol hemihydrate tablets (Vagifem) or vaginal cream (Estrace vaginal cream)
Use according to the precise dosing schedule, typically tablets are insert- ed once daily for 2 weeks, then twice per week. Insert tablet using provided applicator at bedtime.
Vaginal cream is applied using a reusable applicator to measure the precise dose; insert into vagina at bedtime.
History of or other risk for thromboembolic events
Suspected or confirmed breast, vaginal, cervical, or endometrial cancer
Undiagnosed vaginal bleeding
Hypertension/Heart Disease/Diabetes mellitus
Gallbladder disease/Kidney Dysfunction
Rifampin, ritonavir (Norvir), phenobarbital, carbamazepine (Tegretol), primidone (Mysoline), phenytoin (Dilantin), and St. John’s wort can re- duce the effectiveness of estrogens.
Estrogens can reduce the effects of warfarin (Coumadin) and hypoglyce- mic drugs.
Estrogens can increase levels of theophylline (Theo-24), diazepam (Vali- um), chlordiazepoxide (Librium), and tricyclic antidepressants.