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DM2 Sulfonylureas - Glipizide (Glucotrol) Cheat Sheet by

Treats type 2 diabetes mellitus

Medication Name

Glipizide (Gluco­trol)

Therap­eutic Use

Type 2 diabetes mellitus

Adverse Drug Reactions

Nausea, diarrhea

Nursing Interv­entions

Monitor for signs of hypogl­ycemia (diaph­oresis, tachyc­ardia, fatigue, excessive hunger, tremors).
If the client is conscious, give glucose orally in either pill form, 2–3 tsp of sugar, glass of orange juice, honey, or corn syrup dissolved in water.
If the client is not conscious, give intrav­enous glucose; give parenteral glucagon if IV not available
Check the client’s blood glucose every 15–20 minutes.
Continue treatment until the blood glucose has returned to the expected reference range and the client is no longer sympto­matic.
Monitor for persistent nausea, vomiting, or diarrhea.
Monitor CBC levels

Drug Admini­str­ation

Give orally 30 min before selected meal.
Make sure clients swallow the sustai­ned­-re­lease form whole and do not crush or chew it.

Patient Education

Wear a medical alert bracelet.
Watch for and report symptoms of hypogl­ycemia.
Test blood glucose to confirm.
Consume a snack of carboh­ydr­ates.
Retest in 15 to 20 min and repeat if still low
Carry a carboh­ydrate snack at all times.


Pregnancy, lactation (insulin is recomm­ended during pregnancy)
Diabetic ketoac­idosis


Renal or hepatic dysfun­ction
Adrenal or pituitary insuff­iciency


Alcohol poses a risk for a disulfiram (Antab­use­)-like reaction (nausea, palpit­ations, flushing) and increases hypogl­ycemic effects.
Sulfon­amide antibi­otics, NSAIDs, oral antico­agu­lants, salicy­lates, monoamine oxidase inhibi­tors, and cimetidine (Tagamet) increase hypogl­ycemic effects.
Thiazides counteract hypogl­ycemic effects
Beta blockers mask manife­sta­tions of hypogl­ycemia


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