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Used in treatment of benign prostatic hypertrophy and pattern hair loss. Reduces risk of prostate cancer.
5 Alpha Reductase Inhibitors
Prototype Med |
finasteride (Propecia and Proscar) |
Other Meds |
dutasteride (Avodart) |
Action: Act by inhibiting the enzyme 5 alpha reductase which chages testosterone into 5 alpha dihydrotestosterone or DHT in the prostate gland.
Therapeutic Use
Treatment of benign prostatic hypertrophy (also reduces the risk of prostate cancer) |
Treatment of male pattern hair loss (Propecia) |
Adverse Drug Reactions
Reduced libido and ejaculate volume |
Reduced prostate-specific antigen (PSA) levels |
Gynecomastia (males) |
Nursing Interventions
Tell clients about the possibility of reductions in libido and ejaculate volume. |
Obtain a baseline PSA level and monitor periodically. |
Expect PSA levels to decline with therapy. |
Evaluate any increases in PSA level, as they may indicate prostate cancer or nonadherence to therapy. |
Monitor for breast enlargement. |
Evaluate if there is concern for body image. |
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Administration
Take orally, with or without food. |
Crush the tablets if needed. |
Expect drug therapy to be lifelong. |
Ensure that women do not handle the drug, especially if crushed, due to the possibility of transdermal absorption. |
Expect therapeutic effects to take 6 to 12 months. |
Patient Education
Expect decreases in libido and ejaculate volume. |
Undergo regular prostate cancer screenings. |
Report breast enlargement. |
Contraindications
Pregnancy (teratogenic) |
Female, children |
Precautions
Liver impairment |
Obstructive uropathy |
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