Cheatography
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Overview of medicinal chemistry
This is a draft cheat sheet. It is a work in progress and is not finished yet.
Medicinal chemistry
Definition: |
Drugs: A medicine or other substances which has a marked effect when taken into body. |
Medicine: A drug or other preparation is taken into body in order to treat or prevent disease |
Drug Name: Adopted by company during development |
Proprietary Name: Registered & used by company exclusively |
Systemic Name: By IUPAC rules |
Research Code: Letter & no. For company to identify the particular compound |
Generic Name: Recommended international non proprietary name by WHO when patent has expired |
Classifications of drug |
Chemical Structure:
Common skeleton structure
May have same biological activity |
Pharmacological effect:
Same biological outcome, different pathway
Limit drug use eg. :anti-fungal |
Target System:
Same biological outcome different pathway(Specific chemical messengers)
Synthesis,mimics,blocks,degradation |
Target Molecule:
Affects specific enzyme, neurotransmitter or receptors
Same biological outcome, same pathways
Similar structure |
Membrane Permeability coefficient : |
1. Depend on lipophilicity & molecular charge
2. Large coefficient = Good permeability ; Small coefficient = Poor permeability- highly charged (+/-)
3. ~80% drug posses a charge, depend on pH of the medium & pKa of a FG |
|
pKa
Bronsted-Lowry Theory |
HA + B ⇌ A- + HB+
Acid + Base ⇌ Conjugated Base + Conjugated acid |
Henderson-Hasselbalch |
pKa = pH- Log( [Conjugated base]/[Weak acid])
pKa: pH at which 50% of substance is ionized |
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pKa (copy)
Bronsted-Lowry Theory |
HA + B ⇌ A- + HB+
Acid + Base ⇌ Conjugated Base + Conjugated acid |
Henderson-Hasselbalch |
pKa = pH- Log( [Conjugated base]/[Weak acid])
pKa: pH at which 50% of substance is ionized |
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