Show Menu
Cheatography

NSAIDS Cheat Sheet by

List of nsaids medication

MOA

Enzyme targets by NSAIDs

REMEMBER

COX-2
= C = K = Kidney
= 2 = B = Brain

COX-1 = 1 = Number 1 so good at affecting everything else

Chemical mediators of inflam­mation

extra inform­ation
 

Common NSAIDs

NOTES:
* Cannot take other NSAIDs before taking aspirin because they may prevent aspirin action
* COX-2 selective has less AE of GI
* Naproxane less CVS effect dt antith­rom­boxane

REMEMBER:

"­ABC­DiN­"
- Aspirin
- iBuprofen, Naproxen
- COX-2 selective
- Diclofenac

COX-2 Selective, remember "­-co­xib­"
main: Celecoxib

Beneficial effects of inhibition PG synthesis

Analgesia
↓Brady­kinin, 5-HT (serot­onin)
Antipy­retic
↓ IL-1, reset thermostat
Anti-i­nfl­amm­atory
↓ PGE2, PGI1
Antith­rom­botic
by aspirin at low dose (permanent acetyl­ation, inhibit platelet activa­tion)
Arteriosus (NSAIDs for closure of patent ductus arteri­osus)
 

Adverse effect

nSAIDS
Allergy
Impaired
Renal function
Damage stomach wall (ulcer)

Contra­ind­ication

Bleeding
Avoid in patient:
-Anticoagulants
-Pregnancy 3rd trimester (premature close DA, risk bleeding)
Inhibit platelet cyclox­ygenase (COX), thereby blocking the formation of thromb­oxane A2 (TXA2) and impairing TXA2 dependent platelet aggreg­ation
Asthma
Inhibition of COX pathway shifts the arachi­donic acid metabolism to Lipoxy­genase (LOX) pathway leading to increased leukot­riene synthesis
Allergy
Stomach (Peptic ulcer, gastritis)
Mucosal damage by –
COX-1 inhibi­tion: Reduced blood flow
Topical irrita­tion: Epithelial damage
COX-2 inhibi­tion: Leukocyte adherence
*Can prescribe PPI for gastro­-pr­ote­ction
CVS event
angina, recent cardiac bypass usrgery, MI, any CV events
REMEMBER
CBARS
 

Comments

No comments yet. Add yours below!

Add a Comment

Your Comment

Please enter your name.

    Please enter your email address

      Please enter your Comment.

          Related Cheat Sheets

          Pharmacology Musculoskeletal Cheat Sheet

          More Cheat Sheets by aina

          Pharmacology Musculoskeletal Cheat Sheet
          Arrhytmia Cheat Sheet