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Atypical Anxiolytic/ Non-barbiturate Anxiolytics Cheat Sheet by

Busprione Panic disorder




The exact antian­xiety mechanism of this medication is unknown. This medication binds to serotonin and dopamine receptors. Dependency is much less likely than with other anxiol­ytics, and use of buspirone does not result in sedation or potentiate the effects of other CNS depres­sants. It carries no risk of missuse.
The major disadv­antages is that antian­xiety effects develop slowly. Initial responses take a week, and at least 2 to 4 weeks for it to reach its full effects. As a result, buspirone is taken on a scheduled basis, and is not suitable for PRN usage.

Therap­eutic Uses

Panic Disorder
Social Anxiety Disorder
Obsessive Compulsive and related Disorder
Trauma and Stressor Related Disorder (PTSD)
Genera­lized Anxiety Disorder (GAD)


Client Education
Dizziness, nausea, headache, lighth­ead­edness, agitation
Take with food to decrease nausea. Avoid activities that require alertness until effects are known. Most adverse effects are self-l­imiting
Increase fiber and fluids
Suicidal Ideation
Monitor and report manife­sta­tions of depression and thoughts of suicide

Contra­ind­ica­tions/ Precau­tions

Buspirone is pregnancy risk category B.
Buspirone is not recomm­ended for use by clients who are pregnant or breast­fee­ding.
Use buspirone cautiously in order adult clients and clients who have liver and/or renal dysfun­ction.
Buspirone us contra­ind­icated for concurrent use with MAOI antide­pre­ssants or for 14 days after MAOIs are discon­tinued. Hypert­ensive crisis can result


Client Education
Erythr­omycin, ketoco­nazole, St. John's Wort, and grapefruit juice can increase the effects of buspirone
Avoid the use of these antimi­crobial agents. Avoid herbal prepar­ations containing St. John's worts. Avoid drinking grapefruit juice.

Nursing Admini­str­ation

Client Education
Labeled for short term treatment of anxiety, but has shown therap­eutic benefits for as long as a year.
Take the medication with meals to prevent gastric irrita­tion. Effects don't occur immedi­ately. It can take a week to notice the first therap­eutic effects and 2 to 4 weeks for the full benefit. Take on a regular basis and not PRN. Tolerance, depend­ence, or withdrawal effects are not an issue with this medica­tion.


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