Show Menu

Atypical Antidepressants Cheat Sheet by

Bupropion antidepressants




Acts by inhibiting norepi­nep­hrine and dopamine uptake, and is referred to as a norepi­nep­hri­ne-­dop­amine reuptake inhibitor.

Therap­eutic Uses

Treatment for depression
Altern­ative to SSRIs and SNRIs for clients unable to tolerate sexual dysfun­ction adverse effects of these antide­pre­ssants
Aid for smoking cessation
Prevention of seasonal pattern depression
Altern­ative treatment choice for attent­ion­-de­ficit disorder


Nursing Action and Education
Headache, dry mouth, GI distress, Consti­pation, Increased heart rate, Hypert­ension, Restle­ssness, and Insomnia
Treat headache with mild analgesic. Observe for effects and notify the provider if intole­rable. Sip on fluids to treat dry mouth and increase dietary fiber to prevent consti­pation.
Nausea, Vomiting, Anorexia, Weight Loss
Monitor weight and food intake
Avoid admini­stering to clients at risk for seizures (a client who have head injuries). Monitor for seizures, and treat accord­ingly.

Contra­ind­ica­tions/ Precau­tions

Bupropion is a pregnancy risk category B.
Notify the provider if pregnant or breast­fee­ding. The provider will determine is the risks of taking the medication out-weigh the benefiits.
Contra­ind­icated in clients taking MAOIs.
Contra­ind­icated for clients who have seizure disorders or eating disorders.


Nursing Action
MAOIs (phene­lzine) increase the risk for toxicity
MAOIs should be discon­tinued 2 weeks prior to beginning treatment with bupropion.




Referred to as a seroto­nin­-no­rep­ine­phrine disinh­ibitor.
It increases the release of serotonin and norepi­nep­hrine by blocking the presyn­aptic receptors, and thereby increases thee amount of neurot­ran­smi­tters available for impulse transm­ission.

Nursing Action

Therap­eutic effects can occur sooner with less sexual dysfun­ction than with SSRIs
Mirtaz­apine is generally well tolerated. Clients can experience sleepiness that can be exacer­bated by other CNS depres­sants (alcohol, benzod­iaz­epi­nes), weight gain, and elevated choles­terol.

Client Education

Take at bedtime, can be used as sleep aid.




Both blocks serotonin and works with a serotonin agonist at receptor site (first medication to work in this way).

Nursing Action

Contra­ind­icated with SSRIs and SNRIs (serotonin syndrome), and other serotonin receptor agonists (buspirone and phenot­hia­zines). Stop MAOIs at least 14 days before starting vilazo­done.
Teach manife­sta­tions of serotonin syndrome to client and instruct them when to notify provider.
Monitor for sucidal ideation
Many adverse effects are similar to those of SSRIs and SNRIs.
Take with food to help increase absorp­tion.

Client Education

Avoid grapefruit juice while taking Vilazodone because grapefruit juice inhibits CYP3A4 metabolism resulting in an increase in the medication blood level.




Select­ively inhibits the reuptake of serotonin and norepi­nep­hrine.

Nursing Action

Rapidly absorbed in 1 hr when taken without food.
Adverse effects are sleepi­ness, headache, dizziness, blurred vision, dry mouth, nausea, consti­pation, weight gain, and sexual dysfun­ction
Stop MAOIs at least 14 days before starting nefazo­done.


Trazodone ER


Moderate selective blockage of serotonin receptors, which allows more serotonin to be available for impulse transm­ission.

Nursing Action

Usually used with another antide­pre­ssant agent.
Sedation is a potential problem, can be indicated for a client who has insomnia.
Priapism is a potential adverse effect. Instruct clients to seek medical attention immedi­ately if this occurs
Don't drink grapefruit juice as it inhibits CYP3A4 metabolism resulting in an increase in the medication blood level resulting in toxicity.


No comments yet. Add yours below!

Add a Comment

Your Comment

Please enter your name.

    Please enter your email address

      Please enter your Comment.

          Related Cheat Sheets

          Introduction to Pharmacology Cheat Sheet
          Drug Classes & Actions : NSAIDs Cheat Sheet

          More Cheat Sheets by adrianao

          Sedative Hypnotic Anxiolytics: Benzodiazepines Cheat Sheet