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TCA cycle3 Cheat Sheet by

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Disruption of TCA cycle may cause health issue

 

phosph­atase deficiency

pyruvate dehydr­ogenase is always phosph­ory­lated and thus inactive.
Conseq­uently, glucose is processed to lactate rather than acetyl CoA.
This condition results in unremi­tting lactic acidos­is—high blood levels of lactic acid.
. In such an acidic enviro­nment, many tissues malfun­ction, most notably the central nervous system.
Nausea­,Vo­mit­ing­,Ab­dominal pain,A­nxi­ety...
 

Summary

Pyruvate Dehydr­ogenase Links Glycolysis to the Citric Acid Cycle
Oxidative decarb­oxy­lation, from pyruvate to acetyl CoA, Mt
The Citric Acid Cycle Oxidizes Two-Carbon Units
8 steps, 3 irreve­rsible steps, 3 NADH, 1 FADH2, 1 ATP, 2 CO2
Entry to the Citric Acid Cycle and Metabolism Through It Are Controlled
PDH, isocitrate dehydr­oge­nase, alpha-­Ket­ogl­utarate dehydr­ogenase
The Citric Acid Cycle Is a Source of Biosyn­thetic Precursors
Citrate, alpha-­ket­ogl­uta­rate, succinyl CoA, oxaloa­cetate
 

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