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Metabolism
Metabolism is the chemical reactions in the body's cells that change food into energy. |
Catabolism |
Breaking down |
Anabolism |
Building up |
Metabolism of Carbohydrates |
Glycolysis and Gluconeogenesis |
Citric Acid Cycle (TCA cycle, Krebs cycle) |
Oxidative Phosphorylation |
ATP
ATP is the nucleotide known in biochemistry as the "molecular currency" of intracellular energy transfer. It provides energy for processes that build molecules and tissues, to transport molecules across the cell membrane, to facilitate enzyme activities, to facilitate motion, and is the product of a few steps in metabolism. |
ATP is able to store and transport chemical energy within cells, and also plays an important role in the synthesis of nucleic acids. |
ATP (Adenosine triphosphate) to become ADP (Adenosine diphosphate) – one phosphate loss; then can be back to ATP again. |
Enzyme control the breaking and making of ATP |
ATP hydrolysis
Happens in Glycolysis, is how the cell breaks down ATP the use its energy. |
Hydro - is greek for "water" |
Lysis - is greek for "to split" |
in ATP hydrolysis, water is used to split apart ATP to create ADP to get ENERGY. |
ATP hydrolysis happens after the bulk of the energy is made in oxidative phosphorylation too! |
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Reactants
ATP + H2O -> ADP + inorganic phosphate |
Energy is generated/released by this reaction(30.5 kJ/mol) |
y subunit linked alpha and beta
y subunit linked alpha and beta
Each 360-degree rotation of the γ subunit leads to the synthesis and release of three molecules of ATP. |
In the "open" state, ADP and phosphate enter the active site; |
in the "loose" state.The protein closes up around the molecules and binds them loosely. |
In the "tight" state, the enzyme changes shape again and forces these molecules together to form ATP molecule. |
Alpha subunit is a regulatory subunit. |
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Binging-change mechanism for ATP synthase
Stoichiometry of ATP synthesis
Movement across mitochondrial membrane
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