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Outline
Glycolysis Is an Energy-Conversion Pathway in Many organisms |
The Glycolytic Pathway Is Tightly Controlled |
Glucose Can Be Synthesized from Non-carbohydrate Precursors |
Gluconeogenesis and Glycolysis Are Reciprocally Regulated |
Glycolysis
the sequence of reactions that metabolizes one molecule of glucose to two molecules of pyruvate with the concomitant net production of two molecules of ATP. |
Glycolysis is an ancient pathway employed by a host of organisms. |
This process is anaerobic (i.e., it does not require O2), in as much as it evolved before the accumulation of substantial amounts of oxygen in the atmosphere. |
Pyruvate can be further processed anaerobically to lactate or ethanol. |
Under aerobic conditions(need O2), pyruvate can be completely oxidized to CO2, generating much more ATP. |
Position of glycolysis: cytoplasm |
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Glucose generated from dietary Carbohydrates
Glycolysis
Stage 1: conversion of glucose into fructose 1,6-bisphosphate, and cleavage into two three-carbon fragments; |
stage 2: ATP is generated when the three carbon fragments are oxidized to pyruvate. |
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Diverse fates of pyruvate
Significance of glycolysis
Fermentations provide usable energy in the absence of oxygen |
- obligate anaerobes: Clostridium tetani (破傷風杆菌), Clostridium botulinum (肉毒杆菌) |
- intense exercise |
- food industry: sour cream, yogurt, various cheeses, beer, wine, and sauerkraut |
Maintaining redox balance
The NADH produced by the glyceraldehyde 3-phosphate dehydrogenase reaction must be reoxidized to NAD+ for the glycolytic pathway to continue. In alcoholic fermentation, alcohol dehydrogenase oxidizes NADH and generates ethanol. In lactic acid fermentation (not shown), lactate dehydrogenase oxidizes NADH while generating lactic acid. |
Glycolysis of other hexoses
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