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Additional Drug Overdoses and Treatments (M-V) Cheat Sheet (DRAFT) by

This is a draft cheat sheet. It is a work in progress and is not finished yet.

MTX, METHEM­OGL­OBI­NEMIA, 'SHROOMS

MTX
Leucovorin 
(Folinic acid)

Levole­uco­vorin 
(Fusileer)
Glucar­pidase 
(Voraxaze)
METHEMO-
GLOBINEMIA
Methylene blue 
(ProvayBlue)

     - Contra: G6PD deficient pts
     - Avoid admin w/ SSRIs and SNRIs
MUSHROOMS
(amato­xin­-co­nta­ining)
Supportive care
Silibinin 
(Legalon SIL)

     - Flavonoid ini milk thistle
     - Hepatoprotective
Atropine
     - if severe muscarinic symptoms
     - Bradyc­ardia

NAPHTH­ALENE, NEOSTI­GMINE, NICOTINE

NAPHTH­ALENE 
(from mothballs)
Supportive care
Methylene blue 
(Prova­yBlue)
NEOSTI­GMINE
PYRIDO­STI­GMINE
(antic­hol­ine­sterase meds)
Pralidoxime 
(Protopam)

      - counteracts muscle weakness
     - counteracts respiratory depression
NICOTINE 
(including e-cigs)
Supportive care
Atropine - txs bradycardia
BZDs - txs seizures

ORGANO­PHO­SPHATES (OPs)

INDUSTRIAL INSECT­ICIDES
MALATHION

NERVE (WARFARE) GASES
SARIN, OTHERS
Atropine
Pralid­oxime
Combo
     - 
DuoDote

     - 
ATNAA
Atropine - antich­oli­nergic, blocks SLUDGE symptoms
Pralid­oxime - txs muscle weakness and relieves respir­atory paralysis

PETROLEUM DISTIL­LATES

GASOLINE
KEROSENE
MINERAL OIL
PAINT THINNERS
Supportive care
Do not induce vomiting
Keep pt NPO
     - Aspiration risk

PARALYTICS

ROCURONIUM BROMIDE,
VECURONIUM BROMIDE,
PANCUR­ONIUM BROMIDE
Neosti­gmine methyl­sulfate
     
(Bioxi­verz)
ROCURONIUM BROMIDE,
VECURONIUM BROMIDE
Sugammadex
     
(Bridion)
For reversal of the effects of neurom­uscular blocked induced in adults undergoing surgery
Administer an antich­oli­nergic agent to prevent bradycarda
 ­ ­ ­ ­ - Prior w/ atropine or glycop­yrr­olate or
 ­ ­ ­ ­ - With neosti­gmine
  

SALICY­LATES & STIMULANTS

SALICY­LATES
Sodium bicarb­onate
      - Alkalizing agent
      - Alkalizes urine
     - ↓ drug reabsorption
     - ↑ excretion
STIMULANTS
Amphet­amines

Weight loss drugs

Cocaine

Ephedrine

Caffeine

Theoph­ylline

MDMA (ecstasy)
Supportive care
BZDs
     - tx agitat­ion­/se­izures

TCAs & VALPROATE, ETC

TCAs
Supportive care
Sodium bicarbonate
     - ↓ widened QRS
BZDs
     - tx agitation/seizures
Vasopressors
     - May need for HOTN
VALPROATE OR
TOPIRATE-INDUCED
HYPERAMMONEMIA
Levoca­rnitine 
(Carnitor)