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Loop Diuretics Cheat Sheet (DRAFT) by

Loop Diuretics - pharmacology

This is a draft cheat sheet. It is a work in progress and is not finished yet.


- potent diuretics
- Medica­tions: bumeta­nide, ethacrynic acid, furose­mide, torsemide


- manage edema associated with heart failure and hepatic or renal disease
- control hypert­ension

Mechanism of Action and Drug Effects

- inhibit resorption of sodium and chloride in the thick ascending limb of the loop of Henle
- useful when rapid diuresis is needed due to rapid onset
- activate renal prosta­gla­ndins -> dilation of blood vessels of kidneys, lungs, and ody
- diuretic action continues even when creatinine decreases below 25 mL/min
- reduction in both preload and central venous pressure
- major adverse effect: electr­olyte distur­bances