This is a draft cheat sheet. It is a work in progress and is not finished yet.
Overview
- potent diuretics |
- Medications: bumetanide, ethacrynic acid, furosemide, torsemide |
Indications
- manage edema associated with heart failure and hepatic or renal disease |
- control hypertension |
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Mechanism of Action and Drug Effects
- inhibit resorption of sodium and chloride in the thick ascending limb of the loop of Henle |
- useful when rapid diuresis is needed due to rapid onset |
- activate renal prostaglandins -> dilation of blood vessels of kidneys, lungs, and ody |
- diuretic action continues even when creatinine decreases below 25 mL/min |
- reduction in both preload and central venous pressure |
- major adverse effect: electrolyte disturbances |
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