Urinary Tract Infections
Folate Antagonist; Anti-Infective; Antiprotozoal
Bactrim and Septra
Sulfamethoxazole is only available in combination with trimethoprim. However, trimethoprim is available by itself under the brand name Proloprim
Uninary Tract Infections
Shigella Enteritis (Travelers Diarrhea)
Acute otitis media in children
Adverse Drug Reactions
Nausea, Vomiting, Anorexia
Allergic skin reactions
thrombocytopenia, leukopenia, anemia, agranulocytosis, aplastic anemia
Superinfection – Clostridium difficile-associated diarrhea (CDAD), Candida infections
Severe rash, including Stevens-Johnson syndrome
Decreased kidney or liver function
Hypersensitivity to sulfites used as preservatives (wine, foods), other drugs related to sulfonamides (acetazolamide, thiazide diuretics, tolbutamide)
Suppressed bone marrow
Clients at risk for megaloblastic anemia (clients with alcoholism, pregnant women, clients who are debilitated)
Monitor/Report severe symptoms.
Monitor for rash and hives.
Monitor/Report severe diarrhea
Monitor/Report rash and/or blisters on skin to provider.
Encourage patient to drink plenty of fluids
Monitor I & O
Monitor CBCs and Urinalysis throughout treatment
Available as a fixed-dose combination in tablets, liquid solution, and IV form.
Give oral dose with 8 oz. of water.
Administer intermittent IV infusion slowly (over 60 to 90 min) and with recommended dilution.
Drink at least 1,200 to 1,500 mL water/day during treatment with this drug.
Take with food to minimize GI symptoms.
Report rash, hives, fatigue, pallor, bruising, or new infections to provider
Report watery/bloody diarrhea, pain in mouth, difficulty eating, vaginal itching/burning to provider
Warn clients that sulfonamides decrease the effectiveness of oral contraceptives; use alternate form of contraception.
Report onset of rash and/or blisters on the skin to provider
Women who are pregnant or nursing
Allergy to sulfonamides, trimethoprim, cyclooxygenase-2 inhibitors (celecoxib [Celebrex])
Clients with megaloblastic anemia caused by folic acid deficiency
Children under 2 months
Pharyngitis caused by group A beta-hemolytic streptococci
Severely impaired urine creatinine clearance
Alcohol with the drug may cause a disulfiram-type reaction.
May increase effects of warfarin, phenytoin, tolbutamide (and other sulfonylurea oral antidiabetic drugs).
Taken with methotrexate, clients may have increased immunosuppression.
Reduced effectiveness of oral contraceptives (use alternative contraception).