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Urinary Tract Antiseptics
Urinary Tract Antiseptics
Prototype Med |
Nitrofurantoin |
Other Meds |
Methenamine |
ACTION : Broad spectrum urinary antiseptic with bacteriostatic and bactericidal action. It injures bacteria by damaging DNA.
Therapeutic Uses
Acute UTIs |
Prophylaxis for recurrent lower UTIs |
Nursing Interventions
Monitor/Report GI Symptoms (may reduce or change) |
Monitor/Report Respiratory Symptoms (may discontinue) |
Monitor/Report for Neuropathy |
Monitor lab values of blood components |
Monitor I&O and bowel function |
Patient Education
Take with food or milk |
Report dyspnea/fever/cough to provider |
Report numbness/tingling/weakness of extremities |
Report fatigue/bruising/repeated infections to provider |
Swallow liquid suspension |
Dilute liquid suspension |
Rinse mouth after taking suspension |
Interactions
Concurrent use with antacids decrease absorption |
Probenecid increases the chance of toxicity |
Avoid drugs with potential for pulmonary toxicity |
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Adverse Drug Reactions
Nausea/Vomiting/Diarrhea |
Acute: Chills/Fever/Cough (2-4 days) |
Subacute: Shortness of breath (weeks to months) |
Permanent peripheral neuropathy |
Anemia/Hemolytic Anemia/Thrombocytopenia/Neutropenia |
Tooth Staining (liquid suspension) |
Brown Urine (harmless) |
Dizziness/Drowsiness/Headache |
Photosensitivity |
Pulmonary Distress |
Administration
Oral Capsules (do not crush or chew) |
Macrodantin, Macrobid |
Liquid Suspension (dilute in milk or juice) |
Furadantin |
Rinse mouth after taking liquid suspension
Contraindications
Allergy to nitrofurantoin |
Impaired kidney function |
History of jaundice caused by gallbladder disease |
Pregnancy at more than 38 weeks’ gestation |
During labor or delivery, lactating, infants -1 month |
Precautions
Asthma, Liver/Kidney disease |
Electrolyte Imbalance |
Vitamin B12 deficiency |
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very good work
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