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                    used in the treatment of osteoporosis
                    
                 
                    
        
        
            
    
        
                            
        
                
        
            
                                
            
                
                                                
                                
    
    
            Medication Name
        
                        
                                                                                    
                                                                                            Prototye Med  | 
                                                                                                                        alendronate (Fosamax)  | 
                                                                                 
                                                                                            
                                                                                            Other Meds  | 
                                                                                                                        risedronate (Actonel)  | 
                                                                                 
                                                                                            
                                                                                            |   | 
                                                                                                                        Ibandronate (Boniva)  | 
                                                                                 
                                                                         
                            Drug Class: Bone Resorption Inhibitor 
Action: decrease bone resorption by inhibiting activity of osteoclasts  
                             
    
    
            Therapeutic Use
        
                        
                                                                                    
                                                                                            Prevention and treatment of postmenopausal osteoporosis, glucocorticoid related osteoporosis, age-related osteoporosis in men  | 
                                                                                 
                                                                         
                             
    
    
            Advese Effects
        
                        
                                                                                    
                                                                                            Esophagitis  | 
                                                                                 
                                                                                            
                                                                                            Gastrointestinal disturbances (nausea and vomiting, abdominal pain)  | 
                                                                                 
                                                                                            
                                                                                            Muscle and joint pain  | 
                                                                                 
                                                                                            
                                                                                            Eye pain and vision changes  | 
                                                                                 
                                                                         
                             
    
    
            Nursing Interventions
        
                        
                                                                                    
                                                                                            Give drug with 6–8 oz. of water.  | 
                                                                                 
                                                                                            
                                                                                            For 30 minutes after taking drug, have clients:  | 
                                                                                                                        Remain in upright position.  | 
                                                                                 
                                                                                            
                                                                                            |   | 
                                                                                                                        Avoid eating or drinking anything other than water.  | 
                                                                                 
                                                                                            
                                                                                            |   | 
                                                                                                                        Avoid giving calcium supplement or antacid.  | 
                                                                                 
                                                                                            
                                                                                            Give analgesic for muscle and joint pain.  | 
                                                                                 
                                                                                            
                                                                                            Monitor clients for changes in vision.  | 
                                                                                 
                                                                         
                             
    
    
            Administration
        
                        
                                                                                    
                                                                                            Give drug 30 minutes before breakfast with a full glass of water.  | 
                                                                                 
                                                                                            
                                                                                            Have client sit or stand for 30 minutes after administration  | 
                                                                                 
                                                                                            
                                                                                            Avoid giving calcium-containing drugs/supplements within 30 minutes of administration  | 
                                                                                 
                                                                         
                             
                             | 
                                                                              | 
                                                        
                                
    
    
            Patient Education
        
                        
                                                                                    
                                                                                            Instruct clients to take drug with full glass of water.  | 
                                                                                 
                                                                                            
                                                                                            Instruct clients to do the following for 30 minutes after taking drug:  | 
                                                                                                                        Sit or stand up.  | 
                                                                                 
                                                                                            
                                                                                            |   | 
                                                                                                                        Avoid eating or drinking anything other than water.  | 
                                                                                 
                                                                                            
                                                                                            |   | 
                                                                                                                        Avoid taking calcium supplement or antacid.  | 
                                                                                 
                                                                                            
                                                                                            Advise clients to take analgesic for muscle and joint pain and report pain that persists.  | 
                                                                                 
                                                                                            
                                                                                            Instruct clients to report changes in swallowing or vision to provider  | 
                                                                                 
                                                                         
                             
    
    
            Contraindications
        
                        
                                                                                    
                                                                                            Esophageal strictures/disorders or difficulty swallowing  | 
                                                                                 
                                                                                            
                                                                                            Clients unable to sit up for 30 minutes after administration  | 
                                                                                 
                                                                                            
                                                                                            Renal insufficiency  | 
                                                                                 
                                                                                            
                                                                                            Hypocalcemia  | 
                                                                                 
                                                                         
                             
    
    
            Precautions
        
                        
                                                                                    
                                                                                            Upper gastrointestinal disorders  | 
                                                                                 
                                                                                            
                                                                                            Infection  | 
                                                                                 
                                                                                            
                                                                                            Liver disease  | 
                                                                                 
                                                                                            
                                                                                            Heart failure  | 
                                                                                 
                                                                         
                             
    
    
            Interactions
        
                        
                                                                                    
                                                                                            Calcium supplements and dairy products decrease absorption when given within 30 minutes of each other  | 
                                                                                 
                                                                         
                             
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