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Poxviridae Structure and Replication Cheat Sheet by

Structure, Genome Organisation and Replication

Structure

Structure

Spherical Shaped
Enveloped virus
One lipid membrane
Outer layer
Corrugated due to protru­sions
Internal Core
Dumbbell shaped
Lateral bodies
Two present in the concav­ities between outer layer and Core
Outer core wall
Palisade structure with T-shaped spike proteins
Inner Core wall
Smooth

Proteins

Attachment
A17, A25, A26, A27, D8, H3
Entry
Entry Fusion Comple­x-A16, A21, A28, F9, G3, G9, H2, I2, J5, L1, L5, O3
Redox active proteins
E10, A2.5, and G4
Phosph­ory­lation
Kinase- F10 & B1
Dephos­pho­ryl­ation
Phosph­otase - H1
Proteo­lytic processing
proteinase - I7

Poster By

Bommana Chanakya
Sushma Bhandarkar
213501003
213501004

Poster By

Bommana Chanakya
Sushma Bhandarkar
213501003
213501004
 

Genome Organi­sation

Genome Organi­sation

Terminal Regions
Has ITRs with secondary hairpin loop structures that connect two DNA strands and contains the variable genes that are respon­sible for host cell intera­ctions
Central Regions
Conserved genes respon­sible for replic­ation and morpho­genesis

Proteins

Attachment
A17, A25, A26, A27, D8, H3
Entry
Entry Fusion Complex - A16, A21, A28, F9, G3, G9, H2, I2, J5, L1, L5, O3
Redox active proteins
E10, A2.5, and G4
Phosph­ory­lation
Kinase - F10 and B1
Dephos­pho­ryl­ation
Phosph­atase - H1
Proteo­lytic processing
Proteinase - I7

Protein

Early Gene Proteins
Inducing prolif­eration of neighb­ouring cells
 
Counte­racting host immune defences
 
Some proteins can induce a second uncoating reaction thereby releasing the viral genome from the core
 
Mediating replic­ation of the genome
 
Protiens In Replic­ation
Viral DNA polymerase
 
Helica­se-­primase
 
Uracil DNA glycos­ylase
 
Single­-st­randed DNA-bi­nding protein
 
DNA ligase
 
Holliday junction resolvase
 
Proteins In Transc­ription
RNA polymerase
 
ETF
 
Capping enzyme
 
VITF-3
 
VLTF-1, VLTF-2, VLTF-3, VLTF-4
 
Release factor Elongation factor
 
Poly(A) polymerase
 
DNA topois­omerase
 

Replic­ation Cycle

Replic­ation process

Attachment
Entry
Early Gene Transc­ription
DNA Replic­ation
Interm­ediate Gene Transc­ription
Late Gene Transr­iption
Assembly
Release

Repliation strategy

Assembly

 

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