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AP Bio - Cell Communication and Cell Cycle Cheat Sheet by

Major contents regarding cell communication and cell cycle

What is Cell Commun­ica­tion?

-- Cell commun­ication is how cells sense and react to their enviro­nment and/or signals from other cells
-- It can be through direct cell-t­o-cell contact
-- It consists of ligands and recept­ors; ligands are molecules that bind to receptors (signals); receptors are proteins that detect external signals (antenna)
-- The signal always come from the exterior of the cell (extra­cel­lular)

Steps of Cell Signaling:

1. Rece­ption -- ligand binds to receptor causing receptor to change shape
2. Tran­sdu­ction -- inform­ation transfer from receptor throughout cell
3. Resp­onse -- how the cell changes

Signal Transd­uction

Unders­tanding Pathway Diagrams

-- Pointed arrows means acti­vates
-- Blunt arrow means inhi­bit
-- For multi-step pathways you should simplify into the overall result
-- Similar to math, if there is two inhibi­tions it would result in an activation

Summary of Cell Signaling

-- Different cell types can have different response to the same ligand because they have different receptors
 

RECEPTION

-- Types of recept­ors:
-- Cell surface recept­ors
Liga­nd-­gated ion channe­ls:
Receptors are ion channels that open and let ions cross the membrane
G protei­n-c­oupled receptors (GPCR):
Receptors are associated with G protein. When the receptor is activated it causes the G protein to activate. The G protein activates enzymes. ligand --> GPCR --> G protein --> enzyme --> second messengers
Receptor tyrosine kinases (RTK):
Kinases are enzymes that add phosphate groups to other molecules. When a ligand binds it turns on kinase activity of RTKs.
-- Intr­ace­llular recept­ors
-- This is when the receptor is in side the cell. Unlike cell surface receptors, the ligands are nonpolar. These regulate gene expres­sion.

Types of Ligand

-- Ligands can be: gases ions, lipids, proteins, amino acids, nucleo­tides, etc

Structure Determines Function

-- Ligand binding to a receptor changes the receptors shape
-- Change in receptor shape = change in receptor functi­on

TRANSD­UCTION

Ampl­ifi­cat­ion
-- When one ligand binding to one receptor it results in many molecules inside the cell
-- Each molecule in the signaling pathway can be recycled
Second Messen­gers
-- These activate many enzymes within the cell
-- For example: Cyclic AMP. The activation of some GPCRs increase cAMP while others decrease cAMP.
-- Activation of GPCRS regulate the production of second messengers
-- cAMP can activate other proteins like protein kinase A which is an important regulator of metabolic pathways
the "­first messen­ger­" is the ligand binding to the receptor
Phos­pho­ryl­ation cascades
-- Phosph­ory­lation changes the shape of protein, in result changes the function

RESPONSE

Common cellular response
Gene expres­sion:
activation of transc­ription of specific genes
Enzyme activa­tion:
turning on kinases
Apop­tos­is:
programmed cell death in which the cell breaks down while protecting neighb­oring cells. It is important for develo­pment and a normal process in healthy organisms
 

CELL CYCLE

-- There are four phases to the cell cycle
G1 (gap 1) = cell growth
S (synth­esis) = DNA replic­ation
G2 (gap 2) = cell growth, prepare for mitosis
M (mitos­is) = cell division

Regulation of Cell Cycle

-- Cyclins are proteins that regulate cyclin­-de­pendent kinases (CDKs)
-- Cyclin­s/CDKs control which phase of the cell cycle a cell is in
-- If the cell is not regulated, it can result in cancer which is abnormal growth due to the continuous progre­ssion through the cell cycle

Diagram of The Cell Cycle

Cell Cycle Checkp­oints

Chec­kpoints determine if the cell is ready to progress to the next phase of the cell cycle
-- G1 checkp­oint:
It checks whether the cell is big enough and has made the proper proteins for the synthesis phase. If not, the cell goes through a resting period (G0) until it is ready to divide.
-- G2 checkp­oint:
It checks whether DNA has been replicated correctly. If so, the cell continues on to mitosis.
-- M checkp­oint:
It checks whether mitosis is complete. If so, the cell divides, and the cycle repeats.

Cell Checkp­oints

MITOSIS

-- Inte­rph­ase
DNA is replic­ated, cell prepare for mitosis. The nuclear envelop are distant and the chromo­somes are in the form of threadlike chromatin.
-- Prop­hase
Chromatin condenses making the chromo­somes visible and nuclear envelop breaks down
-- Meta­phase
The thick, coiled chromo­somes, each with two chroma­tids, become aligned at the equato­ria­l/m­eta­phase plane
-- Anap­hase
Sister chromatids separate and the daughter chromo­somes move toward the poles
-- Telo­phase & Cytoki­nesis
The chromo­somes are at the poles, and are becoming more diffuse. The nuclear envelop is reforming. They cytoplasm may be dividing. Then the division into two daughter cells.

Stages of Mitosis

Mitosis vs. Meiosis

Mitosis vs. Meiosis (conti­nued)

 

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