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  /Title (ap-bio-cell-communication-and-cell-cycle.pdf)
  /Creator (Cheatography)
  /Author (chandaii)
  /Subject (AP Bio - Cell Communication and Cell Cycle Cheat Sheet)
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    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{AP Bio - Cell Communication and Cell Cycle Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{chandaii} via \textcolor{DarkBackground}{\uline{cheatography.com/135022/cs/27926/}}}
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\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}chandaii \\
  \uline{cheatography.com/chandaii} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 13th May, 2021.\\
   Updated 13th May, 2021.\\
   Page {\thepage} of \pageref{LastPage}.
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{What is Cell Communication?}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{-{}- Cell communication is {\bf{how cells sense and react to their environment and/or signals from other cells}}} \tn 
% Row Count 3 (+ 3)
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\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-{}- It can be through direct cell-to-cell contact} \tn 
% Row Count 4 (+ 1)
% Row 2
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\mymulticolumn{1}{x{5.377cm}}{-{}- It consists of {\bf{ligands and receptors}}; ligands are molecules that bind to receptors (signals); receptors are proteins that detect external signals (antenna)} \tn 
% Row Count 8 (+ 4)
% Row 3
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\mymulticolumn{1}{x{5.377cm}}{-{}- The signal {\bf{always}} come from the exterior of the cell (extracellular)} \tn 
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Steps of Cell Signaling:}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{1. {\bf{Reception}} -{}- ligand binds to receptor causing receptor to change shape} \tn 
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% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{2. {\bf{Transduction}} -{}- information transfer from receptor throughout cell} \tn 
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% Row 2
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\mymulticolumn{1}{x{5.377cm}}{3. {\bf{Response}} -{}- how the cell changes} \tn 
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Signal Transduction}}  \tn
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Understanding Pathway Diagrams}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{-{}- {\emph{Pointed arrows}} means {\bf{activates}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-{}- {\emph{Blunt arrow}} means {\bf{inhibit}}} \tn 
% Row Count 2 (+ 1)
% Row 2
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\mymulticolumn{1}{x{5.377cm}}{-{}- For multi-step pathways you should simplify into the overall result} \tn 
% Row Count 4 (+ 2)
% Row 3
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\mymulticolumn{1}{x{5.377cm}}{-{}- Similar to math, if there is two inhibitions it would result in an activation} \tn 
% Row Count 6 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Summary of Cell Signaling}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{-{}- Different cell types can have different response to the same ligand because they have different receptors} \tn 
% Row Count 3 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.43873 cm} x{2.53827 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{RECEPTION}}  \tn
% Row 0
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\mymulticolumn{2}{x{5.377cm}}{{\bf{-{}- Types of receptors:}}} \tn 
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\mymulticolumn{2}{x{5.377cm}}{\{\{ac\}\} -{}- {\bf{Cell surface receptors}}} \tn 
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% Row 2
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{\bf{Ligand-gated ion channels:}} & Receptors are ion channels that open and let ions cross the membrane \tn 
% Row Count 6 (+ 4)
% Row 3
\SetRowColor{white}
{\bf{G protein-coupled receptors (GPCR):}} & Receptors are associated with G protein. When the receptor is activated it causes the G protein to activate. The G protein activates enzymes. ligand -{}-\textgreater{} GPCR -{}-\textgreater{} G protein -{}-\textgreater{} enzyme -{}-\textgreater{} second messengers \tn 
% Row Count 17 (+ 11)
% Row 4
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{\bf{Receptor tyrosine kinases (RTK):}} & Kinases are enzymes that add phosphate groups to other molecules. When a ligand binds it turns on kinase activity of RTKs. \tn 
% Row Count 24 (+ 7)
% Row 5
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\mymulticolumn{2}{x{5.377cm}}{\{\{ac\}\} -{}- {\bf{Intracellular receptors}}} \tn 
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% Row 6
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\mymulticolumn{2}{x{5.377cm}}{-{}- This is when the receptor is in side the cell. Unlike cell surface receptors, the ligands are nonpolar. These regulate gene expression.} \tn 
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Types of Ligand}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{-{}- Ligands can be: {\bf{gases ions, lipids, proteins, amino acids, nucleotides, etc}}% Row Count 2 (+ 2)
} \tn 
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Structure Determines Function}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{-{}- Ligand binding to a receptor changes the receptors shape} \tn 
% Row Count 2 (+ 2)
% Row 1
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\mymulticolumn{1}{x{5.377cm}}{-{}- {\bf{{\emph{Change in receptor shape = change in receptor function}}}}} \tn 
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\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{TRANSDUCTION}}  \tn
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\mymulticolumn{2}{x{5.377cm}}{\{\{ac\}\} {\bf{Amplification}}} \tn 
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-{}- When one ligand binding to one receptor it results in many molecules inside the cell & -{}- Each molecule in the signaling pathway can be recycled \tn 
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% Row 2
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\mymulticolumn{2}{x{5.377cm}}{\{\{ac\}\} {\bf{Second Messengers}}} \tn 
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% Row 3
\SetRowColor{white}
-{}- These activate many enzymes within the cell & -{}- {\bf{For example: Cyclic AMP.}} The activation of some GPCRs increase cAMP while others decrease cAMP. \tn 
% Row Count 13 (+ 6)
% Row 4
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-{}- Activation of GPCRS regulate the production of second messengers & -{}- cAMP can activate other proteins like protein kinase A which is an important regulator of metabolic pathways \tn 
% Row Count 19 (+ 6)
% Row 5
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\mymulticolumn{2}{x{5.377cm}}{{\bf{the "first messenger" is the ligand binding to the receptor}}} \tn 
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% Row 6
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\mymulticolumn{2}{x{5.377cm}}{\{\{ac\}\} {\bf{Phosphorylation cascades}}} \tn 
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% Row 7
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\mymulticolumn{2}{x{5.377cm}}{-{}- Phosphorylation changes the shape of protein, in result changes the function} \tn 
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\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\begin{tabularx}{5.377cm}{x{1.74195 cm} x{3.23505 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{RESPONSE}}  \tn
% Row 0
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\mymulticolumn{2}{x{5.377cm}}{\{\{ac\}\} {\bf{Common cellular response}}} \tn 
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% Row 1
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{\bf{Gene expression:}} & activation of transcription of specific genes \tn 
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% Row 2
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{\bf{Enzyme activation:}} & turning on kinases \tn 
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% Row 3
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{\bf{Apoptosis:}} & programmed cell death in which the cell breaks down while protecting neighboring cells. It is important for development and a normal process in healthy organisms \tn 
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\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{CELL CYCLE}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{-{}- There are {\bf{four phases}} to the cell cycle} \tn 
% Row Count 1 (+ 1)
% Row 1
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\mymulticolumn{1}{x{5.377cm}}{{\bf{G1 (gap 1)}} = cell growth} \tn 
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% Row 2
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\mymulticolumn{1}{x{5.377cm}}{{\bf{S (synthesis)}} = DNA replication} \tn 
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\mymulticolumn{1}{x{5.377cm}}{{\bf{G2 (gap 2)}} = cell growth, prepare for mitosis} \tn 
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\mymulticolumn{1}{x{5.377cm}}{{\bf{M (mitosis)}} = cell division} \tn 
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Regulation of Cell Cycle}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{-{}- Cyclins are proteins that regulate cyclin-dependent kinases (CDKs)} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-{}- Cyclins/CDKs {\bf{control which phase of the cell cycle a cell is in}}} \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{-{}- If the cell is not regulated, it can result in {\bf{cancer}} which is abnormal growth due to the continuous progression through the cell cycle} \tn 
% Row Count 7 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Diagram of The Cell Cycle}}  \tn
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\mymulticolumn{1}{p{5.377cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/chandaii_1620872794_Cell-Cycle-Diagram.jpg}}} \tn 
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\begin{tabularx}{5.377cm}{x{1.69218 cm} x{3.28482 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Cell Cycle Checkpoints}}  \tn
% Row 0
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\mymulticolumn{2}{x{5.377cm}}{{\bf{Checkpoints determine if the cell is ready to progress to the next phase of the cell cycle}}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
-{}- {\bf{G1 checkpoint:}} & It checks whether the cell is big enough and has made the proper proteins for the synthesis phase. If not, the cell goes through a resting period (G0) until it is ready to divide. \tn 
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-{}- {\bf{G2 checkpoint:}} & It checks whether DNA has been replicated correctly. If so, the cell continues on to mitosis. \tn 
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-{}- {\bf{M checkpoint:}} & It checks whether mitosis is complete. If so, the cell divides, and the cycle repeats. \tn 
% Row Count 17 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Cell Checkpoints}}  \tn
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\mymulticolumn{1}{p{5.377cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/chandaii_1620873298_cell-checkpoints_med.jpeg}}} \tn 
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\begin{tabularx}{5.377cm}{x{2.14011 cm} x{2.83689 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{MITOSIS}}  \tn
% Row 0
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-{}- {\bf{Interphase}} & DNA is replicated, cell prepare for mitosis. The nuclear envelop are distant and the chromosomes are in the form of threadlike chromatin. \tn 
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% Row 1
\SetRowColor{white}
-{}- {\bf{Prophase}} & Chromatin condenses making the chromosomes visible and nuclear envelop breaks down \tn 
% Row Count 11 (+ 4)
% Row 2
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-{}- {\bf{Metaphase}} & The thick, coiled chromosomes, each with two chromatids, become aligned at the equatorial/metaphase plane \tn 
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-{}- {\bf{Anaphase}} & Sister chromatids separate and the daughter chromosomes move toward the poles \tn 
% Row Count 20 (+ 4)
% Row 4
\SetRowColor{LightBackground}
-{}- {\bf{Telophase \& Cytokinesis}} & The chromosomes are at the poles, and are becoming more diffuse. The nuclear envelop is reforming. They cytoplasm may be dividing. Then the division into two daughter cells. \tn 
% Row Count 28 (+ 8)
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Stages of Mitosis}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Mitosis vs. Meiosis}}  \tn
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Mitosis vs. Meiosis (continued)}}  \tn
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\mymulticolumn{1}{p{5.377cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/chandaii_1620874517_Meiosis-vs-Mitosis.jpg}}} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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% That's all folks
\end{multicols*}

\end{document}