This is a draft cheat sheet. It is a work in progress and is not finished yet.
Reversible anti-cholinesterase
Physostigmine |
Neostigmine |
Pyridostigmine |
Ambenonoium Cl |
Edrophonuim Cl |
Donepezil"Aricept" |
ttt of glaucome |
ttt of myasthenia gravis |
ttt of myasthenia gravis |
ttt of myesthenia gravis |
|
ttt of Alzheimer's' dimentia |
Antidote to atropine poisoning. |
-Natural |
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longer duration |
Can pass BBB & conjunctiva |
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fewer GI side effects |
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Side effects include nausea, diarrhea, sleeping troubles |
(indirect cholinomimetics)
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Muscarinic agonist
-Bethanechol Cl- |
must not be administered IV or IM routes |
Used for urine retention or abdominal distention (to increase digestion). |
Long acting due to: |
1. Beta methyl |
2. Carbamate ester |
Irreversible ChE inhibitors.
Organophosphorus compounds: insecticide, nerve gases & ttt of glaucoma. |
Antidote: Pralidoxime (ChE reactivator) |
Tetraethyl pyrophosphate |
Anti-muscarinic
Natural |
Synthetic (amino-alcohol-ester) |
Synthetic (amino-alcohol) |
Solanaceous alk. (Atropine & scopolamine) |
Clidinium bromide |
Biperiden |
atropine is used as preanesthtic to decrease oral and pulmonary secretions. |
Used in ttt of spastic colon and peptic ulcer. |
Anti-parkinsonian |
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-It's combined with chlordiazeopoxide in a drug called Normaxin |
Combined with levodopa |
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Its anti-spasmodic and anti-secretory so decreases gastic HCl secretions and abdominal cramping. |
CI in glaucoma |
Contraindicated with glaucoma |
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(Depolarizing) Ganglionic blockers
Nicotine |
Acts as a blocker only in large doses (small doses of nicotine are stimulants) |
Non-depolarizing neuromuscular blockers
Tubocurarine |
Gallamine triethiodide |
Pancuronuim |
Rocuronuim bromide |
-natural- |
Synthetic |
Aminosteroid ms. relaxant |
Aminosteroid ms. relexant |
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muscle relaxant for surgical procedures |
Used for euthansia/lethal injection |
Used as skeletal ms relexant, usually for endotracheal intubation (mechanical ventilation or surgery) |
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Effects are partially reversed by reversible ChE inhibitors. |
Also called curariform or curari-mimmetic drugs.
They relax smooth ms. and used as preanesthetic medication.
They must have quaternary ammonium compounds to have a permanent positive charge so that they never act centrally (never pass BB).
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