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Oxidative Phosphorylation2 Cheat Sheet by

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Electron transport Chain inhibitor

pump1
Rotenone
pump3
Antimycin
pump4
Cyanideco
ATP synthase
Oligomycin
protons
uncoupling agent

Generated

Glycolysis
ATP
2
 
NADH
3-5
Pyruvate metabolism
NADH
5
TCA cycle
ATP
2
 
NADH
6
 
FADH2
2

FMN/FM­NH/­FMNH2

Coenzyme Q

Prosthetic groups of cytoch­romes

 

Iron-s­ulfur protein (Fe-S)

Complex 1

NADH-Q Oxidor­edu­catase
Enormous enzyme (>900 kDa), 46 polype­ptides
FMN, Fe-S clusters
Steps of Electr­on-­Tra­nsfer:
1. Binding of NADH and transfer of its electrons to FMN (prost­hetic group of complex)
2. Electrons are transfered from FMNH2 to a series of iron-s­ulfur clusters (prost­hetic group of complex) -> 2Fe-2S + 4Fe-4S clusters
3. Electrons are shuttled to coenzyme Q (ubiqu­inone)
2 Electrons from NADH to Coenzyme Q -> pumping 4 H+ from matrix to interm­embrane space

Comple­x2&Co­Q(entry point for electrons from FADH2)

 

Complex 3

Electrons Flow from Ubiquinol (QH2) to Cytochrome c Through Q-Cyto­chrome c Oxidor­edu­ctase
Cytochrome b: heme bL and heme bH
Cytochrome c1: heme c1
iron–s­ulfur protein: 2Fe-2S center
Function: catalyse transfer of electrons from QH2 -> oxidized cyt c
pumps 4 H+ out of matrix -> interm­embrane space
Coupling of electron transport from Q -> cyt c and transm­embrane proton transport: Q cycle

Complex 4

Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water
CuA/CuA, heme a, heme a3, CuB
heme a3-CuB is respon­sible for reduction of O2
Oxidation of cyt c coupled to reduction of O2  H2O
Electron transfer coupled to proton pump
pumps 2 H+ from the matrix to interm­embrane space

Flow

 

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