Cheatography
https://cheatography.com
!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Electron transport Chain inhibitor
pump1 |
Rotenone |
pump3 |
Antimycin |
pump4 |
Cyanideco |
ATP synthase |
Oligomycin |
protons |
uncoupling agent |
Generated
Glycolysis |
ATP |
2 |
| |
NADH |
3-5 |
Pyruvate metabolism |
NADH |
5 |
TCA cycle |
ATP |
2 |
| |
NADH |
6 |
| |
|
2 |
Prosthetic groups of cytochromes
|
|
Iron-sulfur protein (Fe-S)
Complex 1
NADH-Q Oxidoreducatase |
Enormous enzyme (>900 kDa), 46 polypeptides |
FMN, Fe-S clusters |
Steps of Electron-Transfer: |
1. Binding of NADH and transfer of its electrons to FMN (prosthetic group of complex) |
2. Electrons are transfered from FMNH2 to a series of iron-sulfur clusters (prosthetic group of complex) -> 2Fe-2S + 4Fe-4S clusters |
3. Electrons are shuttled to coenzyme Q (ubiquinone) |
2 Electrons from NADH to Coenzyme Q -> pumping 4 H+ from matrix to intermembrane space |
Complex2&CoQ(entry point for electrons from FADH2)
|
|
Complex 3
Electrons Flow from Ubiquinol (QH2) to Cytochrome c Through Q-Cytochrome c Oxidoreductase |
Cytochrome b: heme bL and heme bH |
Cytochrome c1: heme c1 |
iron–sulfur protein: 2Fe-2S center |
Function: catalyse transfer of electrons from QH2 -> oxidized cyt c |
pumps 4 H+ out of matrix -> intermembrane space |
Coupling of electron transport from Q -> cyt c and transmembrane proton transport: Q cycle |
Complex 4
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water |
CuA/CuA, heme a, heme a3, CuB |
heme a3-CuB is responsible for reduction of O2 |
Oxidation of cyt c coupled to reduction of O2 H2O |
Electron transfer coupled to proton pump |
pumps 2 H+ from the matrix to intermembrane space |
|
Created By
Metadata
Comments
No comments yet. Add yours below!
Add a Comment
Related Cheat Sheets
More Cheat Sheets by rhettbro