Show Menu
Cheatography

Oxidative Phosphorylation Cheat Sheet by

!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

outlines

Oxidative phosph­ory­lation (Electron transport chain + Chemio­smosis)
Eukaryotic Oxidative Phosph­ory­lation Takes Place in Mitoch­ondria
Oxidative Phosph­ory­lation Depends on Electron Transfer (loss of electrons)
The Respir­atory Chain Consists of Four Complexes: Three Proton Pumps and a Physical Link to the Citric Acid Cycle
A Proton Gradient Powers the Synthesis of ATP
Many Shuttles Allow Movement Across the Mitoch­ondrial Membranes
The Regulation of Cellular Respir­ation Is Governed Primarily by the Need for ATP
Electron transfer potential of NADH and FADH2 -> Phosphoryl transfer potential of ATP

outline

A sedentary male of 70 kg (154 lbs) requires about 8400 kJ (2000 kcal) for a day’s worth of activity.
To provide this much energy requires 83 kg of ATP. However, human beings possess only about 250 g of ATP at any given moment.
The disparity between the amount of ATP that we have and the amount that we require is compen­sated by recycling ADP back to ATP. Each ATP molecule is recycled approx­imately 300 times per day. This recycling takes place primarily through oxidative phosph­ory­lation.

bonding

Overview of oxidative phosph­ory­lation

 

Eukaryotic Oxi_Phos_ take place in Mitoch­ondria

Mitoch­ondria

Humans contain an estimated 14,000 m2 of inner mitoch­ondrial membrane.
The mitoch­ondrial matrix is the site of most of the reactions of the citric acid cycle and fatty acid oxidation. In contrast, oxidative phosph­ory­lation takes place in the inner mitoch­ondrial membrane
The outer membrane is quite permeable to most small molecules and ions because it contains many copies of mitoch­ondrial porin,a 30- to 35-kd pore-f­orming protein also known as VDAC, for voltag­e-d­epe­ndent anion channel.
In contrast, the inner membrane is imperm­eable to nearly all ions and polar molecules.

Electron transfer

Electron transfer

Volt potential difference between NADH and O2 drives electron transport and favors formation of a proton gradient
NADH->­Pum­p1-­>Co­Q->­Pum­p3-­>Cy­tC-­>Pu­mp4­->2­O2-­>2H2O
 

Respir­atory Chain have Four Complexes

Three Proton Pumps and a Physical Link to the Citric Acid Cycle
Electrons are transf­erred from NADH to O2 through a chain of three large protein complexes called NADH-Q oxidor­edu­cta­se(I), Q-cyto­chrome c oxidor­edu­ctase (III), and cytochrome c oxidase (IV).
Electron flow within these transm­embrane complexes leads to the transport of protons across the inner mitoch­ondrial membrane.
A fourth large protein complex, called succ­inate-Q reductase (II), contains the succinate dehydr­ogenase that generates FADH2 in the citric acid cycle.
Oxidor­edu­ctase =~ reductase =~ dehydr­ogenase
Ubiquinone (Coenzyme Q) also carries electrons from FADH2 (generated by citric acid cycle) generated through succin­ate-Q reductase

Electr­ons­flo­wdown an energy gradient from NADHtoO2

Components of mitoch­ondrial etc

 

Comments

No comments yet. Add yours below!

Add a Comment

Your Comment

Please enter your name.

    Please enter your email address

      Please enter your Comment.

          Related Cheat Sheets

          Amino acid,Protein structure Cheat Sheet
          Enzyme Cheat Sheet
          Carbohydrates Cheat Sheet

          More Cheat Sheets by rhettbro

          Glycolysis2 Cheat Sheet
          DNA,Lipid Cheat Sheet
          Glycolysis3 Cheat Sheet