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Pharmacokinetic Calculations WIP Cheat Sheet (DRAFT) by

Pharmacokinetic Calculations and their uses

This is a draft cheat sheet. It is a work in progress and is not finished yet.

Basic Pharmacy Parameters

CL (Clear­ance)
CL is the amount of drug per unit time that is excreted unchanged from body. For example, if liver blood flow is 100 L/H and CL is 50 L/h, then that means half of the blood passing through the liver is cleared of blood.
Vd (Volume of Distri­bution)
Vd is a parameter referring to how much drug is distri­buted within tissue versus plasma. If the Vd is high, there is more drug in plasma than tissue, if it is low, there is more within tissue. Used for calcul­ating loading dose.
F (Bioav­ail­abi­lity)
t½ (Half-­life)
𝜏 (Tau) (Dosing interval)
AUC (Area under time concen­tration curve)
AUC 0-24
Cp (plasma concen­tra­tion)
ke
ka
Css,ave
MDR (Maint­enance Dose Rate)

Important relati­onships

 
 

Basic Formulas

CL
= DR/Css
CL
= Dose/A­UC(N)
ER
= CL * Cp
Vd
= Fu/Fut * Vt
Vd
= A/C
Loading dose
= V * Target plasma concen­tration