UNIT I: Cell
All living things are made up of cell |
Most cells are measured between 1 and 100 μm diameter |
Uni-cellular organisms |
mostly consist of bacteria. |
Multi-cellular |
compose of many types of cell. |
Scientist
Robert Hooke |
- one of the pioneers in studying cells create his own microscope. |
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- an english scientist |
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- one of the first person to perceive cell by slicing a very thin piece of cork and observe under microscope. |
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- he observed, drew, and described what he saw and named it "cells" which derived from Latin word cella, meaning "small room" also cellulae which means six-sided cell of a honeycomb. All of this are written in his book Micrographia (1665). |
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- he only saw the cell wall for cork cells are not alive. |
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Anton van Leeuwenhoek |
- dutch naturalist, who was an expert in grinding lenses, created a microscope that can magnify things up to 270X. |
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- observing drops of rain water, he observed minute living organisms that he named "Animalcules". |
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Robert Brown |
- in 1831, he discovered nucleus in plant cell. The nucleus contains the genetic information in an organism. |
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- discovered the carrier of genetic materials called "Nucleus". |
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Felix Dujardin |
- in 1835, French biologist, discovered the semi-transparent substance he called Sarcode which later changed to protoplasm. |
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- discovered the "protoplasm". |
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Mathias Schleiden |
- a German botanist, scrutinized and proposed his study about the plant. |
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- he concluded that all plants are made up of cell. |
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Theodor Schwann |
- in 1839, a German zoologist also observed and studied about the animal parts. |
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- he concluded that all animals are composed of cells. |
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Rudolf Virchow |
- in 1858, a German physician states that "All living cells come from other existing cells." |
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- this proof justify that the creation of new cells were came from other living cells. |
Cell Theory
l The Cell Theory states that:
1. Cells are the building block and the functional unit of all living organisms it includes the life cycle, metabolic activities, and the ability to transfer character traits.
2. All living organisms are containing one or more cells.
3. Cells arise from the pre-existing cells.
l Modern Cell theory:
1. All living organisms are composed of trillions of cell in their body.
2. Cell is fundamental and building blocks of all living organisms.
3. Cells come from other cells by cell division.
4. The cell consists of genetic material which is passed from generation up to the last generation.
5. All cells are made up of the same in chemical composition. |
Cell Morphology: Cell Structure and Function
Organelles
I Due to advancement of technology the study of cell and its structure broadens, this helps us to understand how cells work and how it affects our daily life.
I Also, we are now able to dissect and identify the different part of cell and its functions.
I This part of cell are called ORGANELLES. |
Three major parts: Basic features of all cell type
Cell Membrane/Plasma Membrane |
Cell membrane is made up of semipermeable membrane that actively facilitates the entrance and exit of materials in and out of the cell. |
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This structure is compose of two layer of phospholipids (Phospholipid bilayer) fats, carbohydrates and protein materials. |
Functions: |
Provide support and maintain cell shape. |
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Regulates the flow of material inside and outside the cell. |
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Act as receptor site and functional carrier of molecule. |
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And provide identification boundary. |
Cell wall |
This is the outermost layer of plant, fungal, and bacterial cell. (Not present in animal cell) . |
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Gives additional support to the cell, prevent water loss and enclose the cell to avoid the invasion of pathogens. |
Three major parts: Cytoplasm
Cytoplasm |
Lies between the cell membrane and nucleus. |
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Consist of a jelly-like substance. |
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This is a place where cell expansion, growth, metabolic activities and cell function happens. |
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Also consist of cytosol, organelles and inclusions. |
Cytosol |
Semi-transparent fluid present in which organelles are suspended. It also gives support and holds the organelles in the cell. |
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Cytoplasmic Organelles
Ribosomes |
re small rounded, dark bodies, which contain proteins and RNA. |
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They connect amino acids to form chains of proteins. |
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Ribosomes does not have a membrane. |
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Can be found in cytoplasm and Rough Endoplasmic Reticulum. |
Endoplasmic Reticulum |
Interconnected tubes and flattened sacs (cisternae) that transports vesicles to carry different substances. |
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Comes in two types: Smooth ER and Rough ER |
Rough ER |
Has a ribosomes in its flattened body. Also manufacture and synthesize proteins. |
Smooth ER |
Has a NO ribosomes in its flattened body. It detoxify drugs and synthesize non-protein substance. |
Golgi Apparatus |
A.K.A. Golgi Bodies, Golgi complex and Dictyosomes. |
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Stacks of flattened sacs that carries protein from RER to the outside part of the cell. |
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Contains enzymes that modify protein, packages and secreted protein. |
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Vesicles are the small of packs of organic materials. |
Mitochondria |
It is known as the "Power house of the cell". |
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It has two layers of membranous sacs, the inside membrane is enfolds to form cristae and encloses by a matrix. |
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This is the location wherein energy produces by synthesis of Adenosine Triphosphate. |
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Organelle responsible for cellular respiration, conversion of energy originating from simple sugar and lipids into ATP energy. It regulates cellular metabolism. |
Vacuoles |
Single membranous sac that function as: |
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Storage of materials and water |
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Releases cellular waste products |
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Conducts intercellular digestion |
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Maintains hydrostatic pressure. |
Vacuoles in Plants |
Plays large a vital role in turgor pressure and serves as for the storage of water. |
Vacuoles in Animals |
Relatively small compare to the vacuoles of plant, for storage of food products. |
Lysosomes |
These single-membranous organelles also digest damage parts of the cell down by nucleic acids and some lipids. The digested products can reuse again by the cell for the synthesis of cellular materials. |
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Are known as "scavenger of the cell“ |
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Membranous bag structure which contain strong hydrolytic enzymes use to digest macromolecules. |
Apoptosis |
The programmed of cell destruction with the use of lysosomal enzymes is important in the process of cell development. |
Glycocalyx |
A.K.A. Cell Coat it is located in the outer part of cell membrane of animal cell. |
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It functions for cell recognition and cellular adhesion. |
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It is also responsible for tissue organization. |
Peroxisomes |
Are membranous sacs that containing oxidative enzymes for the function of detoxifying harmful substance. |
Cytoskeleton |
Composed of collective network of protein filamentous, thread-like structure called microtubules, microfilaments which produce a strong ability to support and maintain the cell shape. |
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It is the fundamental framework of the cytoplasm containing protein filament that assist for the organelles to move inside. |
Plastids |
The largest, rounded membranous organelles that contain DNA usually seen in plants but not common in animal cell. |
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A double-membranous structure enclosed by a thylakoid membrane consists of chloroplasts which contain chlorophyll use by the plants for making coloring pigments in their food through the process of photosynthesis. |
Thylakoid |
Flattened membranous sacs. |
Grana |
Stacked arrangement of thylakoid. |
Stroma |
Space outside the thylakoid which contains enzymes for carbohydrate synthesis. |
Centrosome and Centriole |
The centriole is a small, fibrous structure and cylindrical shape having a mass dense of protoplasm found near the nucleus. |
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Contains nine pairs of peripheral microtubules orthogonally arrange to produce the wall of the cylinder. |
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Present only in animal cell, a pair of centrioles are found inside centrosome which replicates when the cell divides. |
Different Plastids and their coloring pigments
Cell headquarters: Part of Nucleus
Nuclear Envelope |
Consists of two-membranous layer that covers the entire nucleus. |
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It contains thread-like materials called chromatin which is located in a darker area of the nucleus. |
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The nuclear membrane controls the continuous flow of materials inside and outside the nucleus. |
**Nucleoplasm |
Or nuclear sap, contains fluid substance that suspended in the internal part forming the protoplasm of the nucleus also known as Karyoplasm. |
Nucleoulus |
A spherical shape made up of granular structures that found inside the nucleus containing Ribosomal Nucleic Acid (RNA) which rich of protein materials for the protein synthesis and carrying hereditary traits. |
Chromosomes |
These are long thread stands associated with protein materials that suddenly coiled, appear thicker, denser and shorter when cells divide. |
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Carries DNA |
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Also bounded with protein which serves as packaging of deoxyribonucleic acid (DNA) that controls the hereditary characteristics. |
Flagella |
Cytoplasmic projections that made of two central and nine pairs of peripheral microtubules which extend from surface of cell; covered by plasma membrane; many single-celled organisms use them for propulsion and other function of flagella for cell locomotion. |
Cilia |
Relatively short projections that extend from the surface of cell and allowing the materials to move on surface of some tissues in form of waves. |
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Prokaryotic vs. Eukaryotic Cells
- The distinction between prokaryotes and eukaryotes is considered to be the most important distinction among groups of organisms. Eukaryotic cells contain membrane-bound organelles, such as the nucleus, while prokaryotic cells do not.
- Differences in the cellular structure of prokaryotes and eukaryotes include the presence of mitochondria and chloroplasts, the cell wall, and the structure of chromosomal DNA.
- Prokaryotes were the only form of life on Earth for millions of years until more complicated eukaryotic cells came into being through the process of evolution. |
Prokaryotic Cells vs. Eukaryotic Cells
Characteristics of Prokaryotic Cells |
Characteristics of Eukaryotic Cells |
Less complex |
More complex |
No nucleus |
True nucleus |
Mostly unicellular |
Either unicellular or multicellular |
Bacterial cell wall – Peptidoglycan |
Plant cell wall – cellulose Fungi – chitin |
Has a long single strand of DNA plus |
Has two to hundreds of chromosomes per cell |
70’s ribosomes |
80’s ribosomes |
Asexual reproduction by fission, Sexual production unkown |
Asexual reproduction by mitosis and Sexual reproduction by fusion of gametes |
Kingdom Monera (bacteria and cyanobacteria) |
Kingdom of Animalia, Kingdom of Plantae and Kingdom of Fungi |
Prokaryotic Cells vs. Eukaryotic Cells
Cell Structure |
Prokaryotic Cell |
Eukaryotic Cell |
Cell membrane |
Yes |
Yes |
Cell wall |
Yes |
Depends on species |
Centrioles |
No |
yes |
Chromosomes |
One long DNA strand |
Many |
Cilia or Flagella |
Yes, simple |
Yes, complex |
Endoplasmic Reticulum |
No |
Yes |
Golgi complex |
No |
Yes |
Lysosomes |
No |
Common |
Mitochondria |
No |
Yes |
Nucleus |
No |
Yes |
Plant Cells vs. Animal Cells
Animal Cell |
Plant Cell |
Has no cell wall. |
Has cell wall. |
Relatively smaller. |
Relatively larger. |
Plastids are usually absent. |
Plastids are present. |
Many small vacuoles. |
Has large central vacuoles. |
Nucleus at the center. |
Nucleus lies on one side of cytoplasm. |
Centrioles are practically present. |
Centrioles are normally absent. |
Lysosomes are present. |
Lysosomes are absent. |
Epithelial Tissue
Epithelial Tissue |
Form the covering of the surfaces of the body located both in internal and external parts. |
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The cells making up the epithelium are often closely bound to one another through specialized structures called Tight Junctions. |
Location: |
External skin |
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Inner lining of the mouth |
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Digestive tract |
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Urogenital tract |
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Lining hollow part of every organ such as heart, lungs, eyes, ears |
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Secretory glands |
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Ventricular system of the brain and central canals of the spinal cord |
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And the uppermost layer of the body, the skin. |
Simple Epithelium |
Epithelial tissue consist of single layer. |
Stratified Epithelium |
Epithelial tissue composed of many layers. |
Two groups of Epithelial Tissue are Simple Epithelium and Stratified Epithelium, but sometimes epithelial tissues are group by: cell layer, cell shape and its function.
Epithelial Tissues
Squamous Cell |
Squamous epithelia are found in places where rapid diffusion is required. It is also called pavement epithelium due to its tile-like appearance. |
Description |
Thin, scaly – look. |
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Flattened on the surface. |
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Fried egg appearance. |
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With rounded nucleus |
Location |
Kidney glomeruli |
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Air sacs |
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Lining of heart |
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Blood vessels |
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Lymphatic vessels |
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Lining of the ventral body cavities |
Function |
Diffusion |
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Filtration |
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Secretion |
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Protection |
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Cuboidal Cell |
An epithelial cell shaped like a cube. This is one of the closely packed cells forming the epithelium. |
Description |
Dice-shape/ Square like shape. |
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With large and spherical nucleus. |
Location |
Kidney Tubules ducts and secretory position of small glands |
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Egg cells |
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Sperm cells |
Function |
Secretion |
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Columnar Cell |
Are epithelial cells which have elongated shape with a height about 4 times the width. They are normal part of functional breast ducts but sometimes they develop in unusual ways or grow more rapidly than one would expect. |
Description |
Taller rather than wide. |
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Column in shape long and rectangular shape with oblong nuclei or elongated nucleus contain goblet cells. |
Location |
Digestive Tubes |
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Gallbladder |
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Excretory Ducts |
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Some glands |
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Bronchi |
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Uterine tubes |
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Uterus |
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Nose |
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Ears |
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Tongues |
Function |
Absorption |
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Secretion |
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Reception |
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Sensory |
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Ciliated Columnar Cell |
Moves mucus and other substances via cilia and is found in the upper respiratory tract. They are the primary target of infection for common cold viruses such as corona virus, influenza virus and rhinovirus. |
Description |
Fine hair like projection. |
Location |
Nose |
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Uterus |
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Fallopian tubes |
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Egg cells |
Function |
Move mucus and other substances across the cell, ciliary action. |
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Pseudostratified columnar cell |
Are found in places such as the trachea and upper respiratory tract, where their cilia and mucous secretion help collet foreign materials so you can cough or sneeze them out. |
Description |
False stratification or appearance. |
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Free surfaces with hair like projection. |
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Nuclei seen at different level that contain goblet cells. |
Location |
Ducts of large glands |
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Ductus difference |
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Trachea |
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Throat |
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Mouth |
Function |
Filtration |
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Absorption |
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Secretion |
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Ciliary Action |
Connective Tissue
Connective Tissue |
Connective tissue is use to connect, bind, holds, and support one part to another part of the body. |
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This is the most vascularized and widely distributed inside the body. |
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Supporting the muscles to produce movements, protect the internal organs, and connects the tissues. |
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Characterized by a large percentage of living cells and non living material known as matrix which is made of ground substance and fibrous structure. |
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Cells of connective tissue is widely apart with each other in a form of matrix. |
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Bone Tissue |
Bone cell (osteocytes) |
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Matrix: Hard or calcified |
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It support, protects, provides lever , storage, hematopoiesis (Blood production). |
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Blood Tissue |
Red blood cell (erythrocytes), white blood cell (leucocytes), and platelets. |
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Matrix: fluid matrix (plasma). |
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To transport materials. |
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Cartilage Tissue |
Chondrocytes |
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Matrix: rubbery collagen, elastic fibrous secretion of chondroitin substance. |
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To support and helps to provide structures. |
Hyaline Cartilage |
Chondrocytes |
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Matrix: firm cartilaginous fiber. |
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To support and cushion properties. |
Fibrocartilage |
Chondrocyte |
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Matrix: Collagenous fibers |
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Absorb compressive shock |
Elastic Cartilage |
Chondrocytes |
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Matrix: elastic fiber. |
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To support the external. |
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Areolar (loose) Tissue |
Mast cell, WBC, fibroblast and macrophages. |
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Matrix: Collagen fiber, elastic fiber and gel-like matrix. |
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Holds and conveys tissue and organ. |
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Adipose Tissue |
Fat cells (adipocytes) |
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Matrix: Reticular structure with collagen fiber. |
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Storage of lipids for energy building. |
Muscle Tissue
Muscle Tissue |
Muscle cells that designed for contraction and movement. |
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These can help us to do work. |
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Muscle cells are also called the muscle fibers. |
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Inside the muscle fiber consists of sarcoplasm known as the cell membrane, sarcolemma as the cytoplasm of the muscle cell and the cell body that containing nucleus located at the center. |
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Skeletal Muscle Tissue |
Striated Voluntary Muscle |
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Long cylindrical shape, bundle form, many nucleus, many striations. |
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Muscle attached to skeleton. |
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Cardiac Muscle Tissue |
Striated Involuntary Muscle |
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Short branching shape, have few striations, single or two nucleus. |
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Muscle of heart. |
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Smooth Muscle Tissue |
Non-striated Involuntary Muscle |
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Spindle in shape, no striations, single nucleus. |
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Muscle of visceral organs. |
Nervous Tissue
Nervous Tissue |
Consists of two types of cells: Conducting cells and Supportive cells. |
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Primary function is to receive stimuli and send the impulse to the and brain. The brain sends back a response via the nerves. |
Two Types of Nervous Tissue |
Conducting Cells |
Neurons are specialized to transmit information throughout the body. |
Supporting Cells |
Transport nutrients from the blood vessels to neurons. |
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Guard against toxin by creating barrier to harmful substances. |
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Neuroglia |
Surround neurons and provide support for and insulation between them. |
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Glial cells are the most abundant cell types in the central nervous system. |
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Neurons |
Are interconnected to transmit signal throughout the Nervous system. |
Consist of two parts: |
1. Cell body or Soma |
Contains the nucleus. Controls the activity of neuron. |
2. Axon |
Conducts impulse away the soma. |
Neurons are classified according to function and structure. |
Base on Function |
Afferent or Sensory Neuron |
Sensory receptor to CNS. |
Efferent or Motor Neuron |
CNS to viscera, muscle or gland. |
Interneurons |
Connection between neurons. |
Base on Structure |
Unipolar |
Single process emerging from the cell body. |
Bipolar |
One dendrite and one axon. |
Multipolar |
Many dendrites and one axon. |
Integration and communication are the two major functions of nervous tissue.
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