Anticoagulants & FibrinolyticsGeneric | Brand | Class | Form | Heparin | UFH (abbreviation) | HMWH | PAR | Enoxaparin | Lovenox | LMWH | PAR | Dalteparin | Fragmin | LMWH | PAR | Warfarin | Coumadin | Coumarin Derivative
(Vit K Antag.) | PO | Dabigatran | Pradaxa | Direct Thrombin Inhibitor | PO | Fondaparinux | Arixtra | Xa Inhibitor | PAR | Apixaban | Eliquis | Xa Inhibitor | PAR | Rivaroxaban | Xarelto | Xa Inhibitor | PO | Edoxaban | Savaysa | Xa Inhibitor | PO | Betrixaban | Bevyxxa | Xa Inhibitor | PO | Alteplase
t-PA | Activase
Cathflo | Fibrinolytic | IV Bolus & Infusion | Reteplase
rPA | Retavase | Fibrinolytic | IV Bolus | Tenecteplase
TNK-tPA | TNKase | Fibrinolytic | IV Bolus |
Drug Site of Action in Coagulation CascadeClass | Drugs | Site of Action | Unfractionated Heparin | Heparin | ATIII, Xa, IIa, VIIa, IXa, XIa, & XIIa | LMWH | Enoxaparin, Dalteparin | ATIII, Xa, IIa | Factor Xa Inhibitor | Fondaparinux | ATIII, Xa | Vit K Antagonist | Warfarin | II, VII, IX, & X | Oral Xa Inhibitors | Apixaban, Rivaroxaban, Edoxaban, Betrixaban | Xa | Direct Thrombin Inhibitors | Dabigatran | IIa (Thrombin) | Fibrinolytics | Alteplase
Reteplase
Tenectaplase | Fibrin |
| | MOA for TherapiesDrug | MOA | Result | Heparin | fxn of ATIII
Significant inhibition of Xa & IIa
Minor Inhibitor of VIIa, IXa, XIa, & XIIa | ACF become inactivated | Enoxaparin
Dalteparin | fxn of ATIII
Significant inhibition of Xa
Some inhibition of IIa | ACF become inactivated | Fondaparinux | fxn of ATIII
Significant inhibition of Xa
Inhibition specific to Xa | ACF become inactivated | Warfarin | Targets Vit K dependent clotting factors (II, VII, IX, & X)
Inhibits VKORC1
| KH2
KH2 is needed as a cofactor for carboxylase enzyme to activate dependent clotting factors
Vit K dependent clotting factors are produced
F II, VII, IX, & X | Apixaban
Rivaroxaban
Edoxaban
Betrixaban | Blocks the active site for Factor Xa
Does not affect antithrombin | Direct inhibition of Factor Xa | Dabigatran | Directly inhibits Factor IIa (Thrombin) | No conversion of fibrinogen to fibrin
Prevents development of a thrombus | Alteplase
(t-PA/r-tPA) | Converts plasminogen to plasmin | Breaks up clot |
ACF: Active Clotting Factors
VKORC1: Vit K Epoxide Reductase - Enzyme responsible for converting Vit K epoxide to its reduced and active form (KH2)
KH2: Active Vit K |
