Cheatography
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Allele
alternative forms of a gene found on the same locus on a chromosome |
Homozygous
2 identical alleles |
BB (homozygous dominant) |
bb (homozygous recessive) |
Law of Segregation (Random Fertilization)
two copies of each hereditary factor (allele) segregate |
offspring acquire one factor from each parent |
Crossing Over
the reciprocal exchange of genetic material between nonsister chromatids during prophase I of meiosis |
Codominance
blood groups |
both alleles are expressed in the heterozygote |
neither is dominant or recessive, but there is no blending |
Pedigree Analysis
pedigree: family tree |
males: squares |
females: circles |
shaded: showing exhibited trait |
half shaded: carrier |
Nature vs. Nurture
nature: genetically determined |
nurture: environmentally determined |
Genes Inherited Located on Sex Chromosomes
in humans: |
~ females: XX |
~ males: XY |
examples of sex linked disorders: |
~ duchenne muscular dystrophy |
~ hemophilia |
~ colorblindness |
Calculate Recombination Frequency
if RF is >50%, the traits are considered to be independently assorted and on DIFFERENT chromosomes |
if RF is <50%, the traits are on the SAME chromosome (any variants from the parent type are due to crossing over) |
Asexual Reproduction
two identical cells |
"clones" |
Examples of Asexual Reproduction
Fission: bacteria |
Fragmentation: starfish |
Budding: coral |
Terms
haploid: cells that contain a single set of chromosomes in an egg or sperm cell (23 gametes) |
diploid: two complete sets of chromosomes (46 somatic) |
triploid: Extra set of chromosomes (69 chromosomes) |
Why are triploid plants seedless?
3 sets of chromosomes make it very unlikely for meiosis to successfully produce spores and gametophytes. Uneven number of chromosomes that won’t pair correctly |
Meiosis Results
4 haploid cells |
not genetically identical |
Mitosis vs. Meiosis
similarities: |
~ prophase, metaphase, anaphase, telophase (pmat) |
~ cell division |
~ cytokinesis: complete division of cytoplasmic contents |
differences: |
~ mitosis: single set of divisions |
~ meiosis: two divisions |
~ mitosis: production of 2n cells |
~ meiosis: production of 1 n cells |
~ mitosis: production of 2 cells |
~ meiosis: production of 4 cells |
|
|
Dominant
a trait is expressed when dominant allele is present |
capital letter (B) |
Heterozygous
one dominant and one recessive allele |
aka hybrids or carriers |
Bb |
Law of Independent Assortment
hereditary factors (alleles) assort into gametes independently from one another (every combination) |
Genetic Variation
crossing over |
independent assortment |
random fertilization |
Epistasis
different genes can interact to control the phenotypic expression of a single trait |
nonallelic genes affect one another |
X-Inactivation in Females
barr bodies |
DNA methylation |
Gene Linkage (Linked Genes)
genes that are on the same chromosome |
usually linked genes will be inherited together (unless separated by crossing over) |
exhibit recombination frequencies less than 50% |
Recombination Frequency Equation (x100%)
Sexual Reproduction
gametes (sperm and egg) |
two parents |
Examples of Sexual Reproduction
internal fertilization: humans, sharks, turtles |
external fertilization: frogs, many fish |
hermaphrodites: most worms, flowering plants |
pollination: flowers |
Meiosis
reduces the chromosome number |
1) Interphase I |
2) Prophase I |
~ synapsis: the lining up of homologous chromosomes |
~ chiasma: exchange of genes between non sister chromatids |
~ crossing over: results in recombination of genes so they assort independently |
3) Metaphase I |
~ lining up of homologous chromosomes |
4) Anaphase I |
~ independent assortment |
5) Telophase I and Cytokinesis I |
6) Prophase II |
7) Metaphase II |
8) Anaphase II |
9) Telophase II and Cytokinesis II |
Horizontal Gene Transfer
donor to recipient cell |
transformation (uptake of external DNA (plasmid)) |
transduction (virus -> bacteria) |
conjugation (bacteria -> bacteria) |
Nondisjunction in Meiosis 1(left) and 2(right)
|
|
Recessive
a trait is masked in the presence of a dominant allele |
lower case letter (b) |
Phenotype
physical characteristic of a trait |
color, size |
Genotype
genetic makeup of the chromosome |
letters (B, b, G, g) |
Incomplete Dominance
neither allele is completely dominant |
hybrids are in between the homozygous traits |
blending |
Polygenic Inheritance
mode of inheritance in which additive effects of two or more genes determines a single trait |
quantitative characters that vary in degree |
AABBCC: dark |
aabbcc: light |
Disorders
Dominant disorders: |
~ anchondraplasia (dwarfism) |
~ huntington's (late acting lethals) |
Recessive disorders: |
~ cystic fibrosis |
~ tay-sachs |
~ sickle cell |
Calculate Chi Square
if we accept the null hypothesis (1:1:1:1), then the genes independently assort on DIFFERENT chromosomes |
if we reject the null hypothesis (1:1:1:1), then the genes are on the SAME chromosome |
Asexual vs. Sexual Reproduction
|
Advantages: |
Disadvantages: |
Asexual: |
do not have to find a mate or expend energy to find a mate |
not much genetic variation |
Sexual: |
genetic variation |
must find a mate and expend energy to find and/or court a mate |
|
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