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Nucleic Acids Cheat Sheet by

Biochemistry - Module 2.4

Nucleic Acids

Biomolecule of heredity
proteom - whole protein in all living things
Nitrogenous Base
Sugar Moiety
Phosphate

STRUCTURES

Nitrog­enous Base
Sugar Moiety
Pyrimidine
2-Deox­yribose
Cytosine
Ribose
Uracil
Thymine
Purine
Adenine
Guanine

FORMS OF DNA

B-DNA
A-DNA
Z-DNA
10 bp
11 bp
12 bp
Right handed
Right handed
Left handed
major & minor groove
 
altern­ating G-C sequence in alcohol or high salt solution
Anti parallel
Chargaff's rule
-for double stranded, %A =%T and %G=%C

DNA Location

 

Structure of DNA

DNA is long polymer of nucleo­tides
Phosph­odi­ester linkage between 3' and 5'
Hbond of nitrog­enous base
Anti-P­arallel

DNA ORGANI­ZATION

Nucleosome
-Funda­mental Unit
 
-(+) Histone and (-) DNA
Histone
-present in quantities that their total mass in chromatin
 
-high proportion of positively charged AA

NUCLEO­SOMES : BEADS ON A STRING

Arrang­ement
Nucleosome
-basic structural unit of chromatin
Chromatin Fiber
-coiled and condensed to form chromo­somes
Loops
-chromatin fiber folded into loops
Chromosome
-H2A, H2B, H3,H4
 

BASE PAIRING

A= T
Apple in Tree
C = G
Car in Garage
A- Adenine
T- Thymine
C- Cytosine
G- Guanine

Bases of DNA and RNA

DNA
RNA
Adenine , Thymine
Adenine , Uracil
Cytosine , Guanine
Guanine , Cytosine
This is Comple­mentary Bases
A-T has 2 Hbonds
C-G has 3 Hbonds

TYPES OF RNA

mRNA
-messenger RNA
-premature, code for proteins
-blueprint
rRNA
-ribosomal RNA
-most abundant , basic structure of ribosome
tRNA
-transfer RNAs
-adaptor between mRNA and AA
snRNA
-small nuclear RNA
-spilicing of pre-mRNA
snoRNA
-small nucleolar RNA
-modify rRNA
other noncoding RNA
-e.g. telemore synthesis
-X chromosome inactivation
-transport of proteins into ER
 

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