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Cheatography

Antidiuretic Hormone - Vasopressin Cheat Sheet (DRAFT) by

Treast diabetes insipidus, which occurs when the body produces an inadequate amount of antidiuretic hormone.

This is a draft cheat sheet. It is a work in progress and is not finished yet.

Medication Names

Prototype Med
desmop­ressin (DDAVP)
 
Stimate
 
Minirin
Other Meds
vasopr­essin (Pitre­ssin)
Vasopr­essin is short acting
Action: causes the reabso­rption of water, as opposed to the excretion of water, and it decreases urine volume.

Therap­eutic Use

Diabetes insipidus
NOTE: For detailed inform­ation about the use of desmop­ressin to treat hemo- philia, see the Hemato­logic System module

Adverse Drug Reactions

Fluid retention (leading to water intoxi­cat­ion), hypona­tremia
Vasoco­nst­riction (vasop­ressin, not desmop­ressin)
Seizures

Nursing Interv­entions

Monitor for headache, confusion, or other signs of water intoxi­cation.
Monitor fluid intake and output.
Monitor serum sodium levels.
Restrict fluid intake when approp­riate.
Recommend diuretic therapy for moderate and severe fluid retention.

Intera­ctions

Carbam­azepine (Tegretol) and chlorp­rop­amide (Diabi­nese) increase antidi­uretic action.
Other vasopr­essors and lithium (Lithobid) decrease antidi­uretic action.
Loop diuretics
Glucoc­ort­icoids
SSRIs, NSAIDs, thiazide diuretics
 

Admini­str­ation

Administer orally, intran­asally, subcut­ane­ously, sublin­gually, or IV.
Spray the nasal form high into the nasal cavity but not into the throat. Blow nose before.
Monitor blood pressure, intake and output, urine and plasma osmola­lity, and creatinine clearance
With IV vasopr­essin, monitor the IV insertion site, as extrav­asation can lead to gangrene
Expect lifelong therapy

Patient Education

Report pounding headache, sleepi­ness, fluid retention, weight gain, and edema.
Limit fluid intake during therapy.
Record fluid intake and output daily
Report chest pain or pressure

Contra­ind­ica­tions

Vasopr­essin
Coronary artery disease
Poor peripheral circul­ation
Chronic nephritis
Desmop­ressin
Electr­olyte imbalances (oral form)
Renal failure
Nephro­genic diabetes insipidus

Precau­tions

Older adults
Cardio­vas­cular disease
Hypert­ension
History of hypona­tremia
Severe heart failure
History of thromb­oem­bolic events