Cheatography
https://cheatography.com
Immunity
Cell-mediated |
Humoral |
4H8C |
B lymphocyte bind Ag -> Plasma cell -> Ab |
Type I (Immediate hypersensitivity/ Allergy)
- IgE mediated |
- Systemic anaphylactic rxn |
1st exposure |
Bind Ab to mast cell |
2nd exposure |
Immediate |
Late phase |
1. Sensitized mast cell bind Ag |
recruit eosinophils |
2. Granulation + release mediators |
same symptoms, last longer |
Clinical features |
H&L: Edema, Mucus Secretion, Sm spasm |
Eosinophil damage epithelial cell, activate mast cell |
| |
Recruited cell amplify& sustain response w/ additional exposure |
Mediators |
Primary |
Lipid |
1. Vasoactive amines (Histamine) |
1. Leukotrients |
2. Enzymes |
2. Prostaglandin D2 |
3. Proteogycans |
3. Platlet-activiating factor |
Cytokines |
--> TNF,IL-1,Chemokines |
Acquired Immunodeficiency syndrome
- Opportunistic infection from HIV (intravenous injection) |
- Bind & kill CD4+ |
- HIV infect CD4+ helper T lymphocytes, Dendritic cell& macrophages |
Hallmark |
- Loss of 1.Cell-mediated & 2. Humoral immunity |
|
|
Type 2 (Antibody-mediated)
- Incompatible blood transfusion |
Cell destruction by |
1. Opsonisation& Phagocytosis |
2. Inflammation |
3. Cellular dysfunction |
Type 3 (Immune complex-mediated)
- Deposition of insoluble Ag-Ab complexes |
Phase I: Formation of blood-borne complex |
II: Deposition in tissues& Activate complement |
III: Attract leukocytes& Vessel+Tissue injury |
Type4 (T cell-mediated)
Direct CD8+ |
Attack all infected cell w./ recognised Ag |
Delayed CD4+ |
Activated T cell release damaging cytokines |
Autoimmunity (Systemic Lupus Erythematosus)
Ag: Self cells e.g. Nucleus |
Ab: Autoantibodies |
- ANA, Antipospholipid, Anticytoplasmic |
Clinical expression |
Rejection of tissue transplants
- After allocrafts |
- Immune system react w./ foreign MHC -> reject& destroy |
- Cell-mediated hypersensitivity & Humoral response |
- Inflammation, necrosis & organ destruction |
|
Created By
Metadata
Comments
No comments yet. Add yours below!
Add a Comment
Related Cheat Sheets
More Cheat Sheets by damn