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Thyroid Antagonists Cheat Sheet by

Drug info for Methimazole

Prototype

Methim­azole

Action

Decreases production or release of thyroid hormones
Inhibits conversion of T4 to T3

Indica­tion: Hypert­hyr­oidism

Grave's Disease
Nodular goiter
Thyroi­ditis
Function thyroid carcinoma
Pituitary adenoma
Thyroid Storm
 

Contra­ind­ica­tions

Pregnancy category D (PTU DOC)
Lactation

Drug Intera­ctions

Antico­agu­lants (monitor INR & bleeding)
BB levels increa­se/­dec­rease & increa­se/­dec­rease methim­azole levels
Digoxin levels increa­se/­dec­rease & increa­se/­dec­rease methim­azole levels

Adverse Effects

Hypoth­yro­idism
Bone marrow suppre­ssion (monitor CBC for pancyt­openia)
 

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