Upper motor lesions (UMNL)
Site of lesion: Cerebral hemispheres, cerebellum, brainstem, spinal cord (above anterior horn) |
Tone: Increased (spacticity) ± clonus (involuntary muscle movement) |
Muscle weakness: - All muscle groups of the lower limb - more marked in the flexor muscle - In the upper limb weakness is more marked in the extensors |
Deep tendon reflexes: Increased (but superficial reflexes such as abdominal reflexes are usually absent) |
Plantar response: Extensor (upping toe) |
Fasciculation: Absent |
Wasting: Late - mainly because of disuse |
Damage: Leads to characteristic set of clinical symptoms known as UMN syndrome |
UMN syndrome
Acute manifestations: 1. Spinal shock - hypotonia & loss of all reflexes on contra-lateral side 2. Relative sparing of trunk muscles - trunk muscles are bilaterally innervated by anterior corticospinal tract, thus lesion of one side of the tract has minimal manifestation; distal muscles, fingers, toes, fine articulations & flexors more than extensors are handled by lateral corticospinal tract, thus affected more |
Late manifestations: 1. Babinski sign 2. Spasticity 3. Hyporeflexia or superficial reflexes 4. Contralateral or ipsilateral involvement 5. Involvement below the lesion 6. Decorticate posture (person is stiff with bent arms, clenched fists, and legs held out straight) 7. Decerebrate posture (arms and legs being held straight out, the toes being pointed downward, and the head and neck being arched backward) |
Lesions
Focal lesion: Disease/pathology that can develop in one specific area of CNS (e.g. nerve compression due to sclerosis) |
Multifocal lesion: Disease/pathology that can develop in multiple specific areas of the nervous system (e.g. multiple sclerosis) |
Diffuse lesion: Disease/pathology that has dispersed affect on the nervous system (e.g. polyneuropathy due to diabetes) |
Disease course & tempo
Degenerative condition: - Slow - Gradual onset - Progressively worsening neurological signs |
Vascular condition: - Abrupt/sudden onset - Flactuating pattern of neurological signs |
Inflammatory condition: - Gradual relapsing-remitting pattern of neurological signs - (symptoms getting worse followed by recovery, after each relapse it gets worse) |
|
|
Lower motor neuron lesion (LMNL)
Site of lesion: Anterior horn cell, nerve roots, peripheral nerves, neuromuscular junction, muscles |
Tone: Decreased (flaccidity) |
Muscle weakness: - More distally than proximally - Both flexors & extensors affected |
Deep tendon reflexes: Reduced or absent |
Plantar response: Normal or absent |
Fasciculation: May be present in anterior horn cell lesions |
Wasting: Usually present |
Damage: Usually causes hyporeflexia, flaccid paralysis, & atrophy |
Neuromuscular junction lesion
Applied example 1
Case: 72-year-old male presents with a right side face and arm weakness - came on over a few months |
Pathological process: Tumour |
Applied example 2
Case: patient presents with a change in cognition, speech, memory, behaviour/personality, & mood |
Pathological process: UMNL, frontal lobe (efferent/motor) |
Applied example 3
Case: patient presents with changes in CN III - XII function |
Pathological process: UMNL, brainstem / spinal lesion |
Applied example 4
Case: patient presents with focal tingling between 4th and 5th finger (no motor abnormalities) |
Pathological process: LMNL, peripheral lesion (ulnar nerve) |
|