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Cheatography

Direct Vasodilators Cheat Sheet (DRAFT) by

Drugs for HF (Module 2 - Pharmacology)

This is a draft cheat sheet. It is a work in progress and is not finished yet.

DIRECT VASODI­LATORS

Minor role in HF treatment
Lower BP
Relax blood vessels

PROTOTYPE DRUG

hydral­azine
(Apres­oline)
[Sometimes used in combin­ation with isosorbide dinitrate (Isordil)]
 

PRIMARY USE

Antihy­per­tensive
Treatment of hypert­ensive emerge­ncies

MECHANISM OF ACTION

hydral­azine vasodi­lates arterial smooth muscles;
isosobride vasodi­lates veins
Both drugs act synerg­ist­ically, thus often combined when treating African Americans for HF

ADVERSE EFFECTS

Stopping abruptly can cause rebound HTN
Other side effects include:
 
- flushing
 
- reflex tachyc­ardia
 
- palpat­ations
 
- lupus-like reaction
 
- hypote­nsion
 
Contra­ind­icated in those with:
tachyc­ardia, angina, or rheumatic heart disease
 

NURSE'S ROLE

Monitor BP & HR
PATIENT TEACHING:
 
Do not stop taking abruptly (rebound HTN)
 
Monitor BP