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Anticoagulation Cheat Sheet (DRAFT) by

Anticoagulation

This is a draft cheat sheet. It is a work in progress and is not finished yet.

Warfarin

Mechanism of Action
Inhibits vitamin K-depe­ndent clotting factors II, VII, IX, X, C and S
Dosing
Titrate to goal INR
Pharma­cok­inetics
Half-life: ~1 week
Protein binding: 99%
Metabo­lism: primarily CYP2C9
Excretion: renally (92%)
Pearls
Today's INR is the result of the last 2 to 3 doses
Dose usually decreases for skinny and older people
Small doses are good for suprat­her­apeutic INR that is trending downward
Not every drig intera­ction is important!

Heparin

Dosing
Mechanism of Action